High-intensity swimming alleviates nociception and neuroinflammation in a mouse model of chronic postischemia pain by activating the resolvin E1-chemerin receptor 23 axis in the spinal cord  

作　　者：Xin Jia Ziyang Li Xiafeng Shen Yu Zhang Li Zhang Ling Zhang 

机构地区：[1]Department of Neurology and Neurological Rehabilitation,Shanghai Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center),School of Medicine,Tongji University,Shanghai,China [2]Department of Rehabilitation,Shanghai Pudong Hospital,Fudan University Pudong Medical Center,Shanghai,China [3]Key Laboratory of Cellular Physiology(Shanxi Medical University),Ministry of Education,and the Department of Physiology,Shanxi Medical University,Taiyuan,Shanxi Province,China [4]Key Laboratory of Central CNS Regeneration(Ministry of Education),Guangdong-Hong Kong-Macao Institute of CNS Regeneration,Jinan University,Guangzhou,Guangdong Province,China

出　　处：《Neural Regeneration Research》2023年第11期2535-2544,共10页中国神经再生研究（英文版）

基　　金：National Key R&D Program of China,Nos.2019YFA0110300 (to LZ),2021YFA1201400 (to LZ);Natural Science Foundation of Shanghai,No.21ZR1468600 (to LZ);Open Fund of the Key Laboratory of Cellular Physiology (Shanxi Medical University),Ministry of Education,No.KLMEC/SXMU-201910 (to XJ)。

摘　　要：Physical exe rcise effectively alleviates chronic pain associated with complex regional pain syndrome type-Ⅰ.However,the mechanism of exe rcise-induced analgesia has not been clarified.Recent studies have shown that the specialized pro-resolving lipid mediator resolvin E1 promotes relief of pathologic pain by binding to chemerin receptor 23 in the nervous system.However,whether the resolvin E1-chemerin receptor 23 axis is involved in exercise-induced analgesia in complex regional pain syndrome type-Ⅰ has not been demonstrated.In the present study,a mouse model of chronic post-ischemia pain was established to mimic complex regional pain syndrome type-Ⅰ and subjected to an intervention involving swimming at different intensities.Chronic pain was reduced only in mice that engaged in high-intensity swimming.The resolvin E1-chemerin receptor 23 axis was clearly downregulated in the spinal cord of mice with chronic pain,while high-intensity swimming restored expression of resolvin E1 and chemerin receptor 23.Finally,shRNA-mediated silencing of chemerin receptor 23in the spinal cord reve rsed the analgesic effect of high-intensity swimming exercise on chronic post-ischemic pain and the anti-inflammato ry pola rization of microglia in the dorsal horn of the spinal cord.These findings suggest that high-intensity swimming can decrease chronic pain via the endogenous resolvin E1-chemerin receptor 23 axis in the spinal cord.

关 键 词：central sensitization chemerin receptor 23 chronic post-ischemia pain complex regional pain syndrome exercise-induced analgesia microglia NEUROINFLAMMATION resolvin E1 spinal cord SWIMMING 

分 类 号：R402[医药卫生—临床医学]