佛山市常住居民有无输精管结扎史与前列腺癌的病因学及危险因素分析  

Etiology and Risk Factors Analysis of Prostate Cancer with or without Vasectomy in Permanent Residents of Foshan

作　　者：张少林[1,2] 苏宗明 李碧怡[1] 苏寒锦 文卫军[4] 宋少康[5] 唐健荣 Zhang Shao-lin;Su Zong-ming;Li Bi-yi;Su Han-jin;Wen Wei-jun;Song Shao-kang;Tang Jian-rong(Department of Urology,Foshan Hospital of Traditional Chinese Medicine,Foshan 528000,Guangdong Province,China;Department of Urology,Foshan Hospital of Traditional Chinese Medicine,Chancheng Hi-tech District Hospital,Foshan 528000,Guangdong Province,China;Department of Urology,Foshan Nanhai District Fourth People's Hospital,Foshan 528200,Guangdong Province,China;Department of Urology,Shunde Hospital,Guangzhou University of Traditional Chinese Medicine,Foshan 528300,Guangdong Province,China;Department of Urology,Foshan Gaoming District People's Hospital,Foshan 528500,Guangdong Province,China;Department of Urology,Sanshui Hospital,Foshan Hospital of Traditional Chinese Medicine,Foshan 528100,Guangdong Province,China)

机构地区：[1]佛山市中医院泌尿外科,广东佛山528000 [2]佛山市中医院禅城高新区医院泌尿外科,广东佛山528000 [3]佛山市南海区第四人民医院泌尿外科,广东佛山528200 [4]广州中医药大学顺德医院泌尿外科,广东佛山528300 [5]佛山市高明区人民医院泌尿外科,广东佛山528500 [6]佛山市中医院三水医院泌尿外科,广东佛山528100

出　　处：《中外医药研究》2022年第15期157-159,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

基　　金：佛山市科技局自筹经费类科技计划项目(编号:2020001005000)。

摘　　要：目的:探讨有无输精管结扎史的佛山市常住居民前列腺癌的病因学及危险因素。方法:筛查2020年1月-2022年1月佛山市禅城区、南海区、顺德区、高明区、三水区>50岁的常住男性居民49.4万人,有输精管结扎史26.21万人,无输精管结扎史23.19万人;确诊为前列腺癌49例(前列腺癌组),无前列腺癌493951人(非前列腺癌组);49例前列腺癌患者中,有输精管结扎史26例(研究组),无输精管结扎史23例(对照组)。进行问卷调查、直肠指检和前列腺特异抗原筛查,确诊是否患前列腺癌。分析两组问卷调查结果。结果:前列腺癌组患者体重指数(BMI)、睡眠质量较差率、不良行为习惯(吸烟、饮酒)率、秃顶率、有家族史率、脑力劳动者率、不良饮食习惯率均高于非前列腺癌组,有婚育史(性活动)率低于非前列腺癌组,差异有统计学意义(P<0.05)。结论:佛山地区常住居民有输精管结扎史和无输精管结扎史的前列腺癌发病率无统计学关联。前列腺癌家族史、脑力劳动、不良饮食习惯、BMI较高、睡眠质量较差、存在显著的不良习惯与秃顶均是诱发前列腺癌的高危因素。Objective:To investigate the etiology and risk factors of prostate cancer among permanent residents of Foshan with or without vasectomy history.Methods:A total of 494,000 male permanent residents aging>50 years old in Chancheng District,Nanhai District,Shunde District,Gaoming District,and Sanshui District of Foshan City were screened from January 2020 to January 2022,including 262,100 cases with a history of vasectomy,and 231,900 cases without a history of vasectomy;49 patients were diagnosed with prostate cancer(prostate cancer group),493,951 cases without prostate cancer(non-prostate cancer group).Amony 49 patients with prostate cancer,26 cases with a history of vasectomy(study group)and 23 cases without a history of vasectomy(control group).Questionnaires,digital rectal examinations and prostate-specific antigen screening were performed to confirm the diagnosis of prostate cancer.The results of the questionnaire survey in both groups were analyzed.Results:The body mass index(BMI),rates of poor sleep quality,bad behavioral habits(smoking and drinking),baldness,family history,brain workers and bad dietary habits were higher in the prostate cancer group than in the non-prostate cancer group,and the rate of having a history of marriage,pregnancy and delivery(sexual activity)was lower in the prostate cancer group than in the non-prostate cancer group,with statistically significant differences(P<0.05).Conclusion:There is no statistical association between the incidence of prostate cancer in permanent residents of Foshan with and without a history of vasectomy.Family history of prostate cancer,brain work,bad dietary habits,higher BMI,poorer sleep quality,presence of significant bad habits and baldness are all high risk factors for predisposing to prostate cancer.

关 键 词：前列腺癌 流行病学 输精管结扎术 前列腺癌 危险因素 

分 类 号：R73[医药卫生—肿瘤]