吡唑-4,5-二酮与马来酰亚胺的MBH反应合成新型马来酰亚胺-吡唑酮MBH碳酸酯类化合物  

Synthesis of Novel Maleimide-Pyrazolone-Derived MBH Carbonates by the Morita-Baylis-Hillman Reaction of Pyrazol-4,5-diones with Maleimide

作　　者：郑金凤 唐雪 潘晓丽[1] 詹固 韩波[1] ZHENG Jinfeng;TANG Xue;PAN Xiaoli;ZHAN Gu;HAN Bo(State Key Laboratory of Southwestern Chinese Medicine Resources,School of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China)

机构地区：[1]成都中医药大学药学院西南特色中药资源国家重点实验室,四川成都611137

出　　处：《合成化学》2023年第3期204-209,共6页Chinese Journal of Synthetic Chemistry

基　　金：四川省科技厅科技项目(2021YJ0402,2019YJ0321)。

摘　　要：Morita-Baylis-Hillman(MBH)碳酸酯作为重要的有机合成中间体,其开发具有重要的意义。本研究以1,4-二氮杂二环[2.2.2]辛烷(DABCO)为催化剂,3-甲基-1-芳基-1H-吡唑-4,5-二酮与N-芳基马来酰亚胺为原料,经Morita-Baylis-Hillman反应等合成了12个新型的马来酰亚胺-吡唑酮MBH碳酸酯类化合物,分离收率为40%~87%,其结构经^(1)H NMR,^(13)C NMR和HR-MS(ESI)表征。Morita-Baylis-Hillman(MBH)carbonates are important organic synthetic intermediates.Thus,developing new types of MBH carbonates is of great significance.A Morita-Baylis-Hillman(MBH)reaction of pyrazolediones with maleimides has been developed in the presence of DABCO.Twelve novel maleimide-pyrazolone-derived MBH carbonates were obtained in 40%~87%yields.The structures were characterized by^(1)H NMR,^(13)C NMR and HR-MS(ESI).

关 键 词：马来酰亚胺 吡唑酮 MBH反应 合成 吡唑 

分 类 号：O621.3[理学—有机化学]