N-乙酰-L-半胱氨酸合成工艺优化  

Optimization of Synthesis Process of N-acetyl-L-cysteine

作　　者：金鑫 郑喆 秦娜 郑汉赟 JIN Xin;ZHENG Zhe;QIN Na;ZHENG Hanyun(ZHEJIANG JINHUA CONBA BIO-PHARM.CO.,LTD,Jinhua 321016)

机构地区：[1]浙江金华康恩贝生物制药有限公司,浙江金华321016

出　　处：《合成化学》2023年第3期238-243,共6页Chinese Journal of Synthetic Chemistry

摘　　要：目前N-乙酰-L-半胱氨酸工艺在碱性条件下进行,该条件对原料L-半胱氨酸有一定的降解作用,从而影响收率。本文对乙酰半胱氨酸合成工艺进行了优化,在近中性的条件下进行乙酰化反应,大幅度地降低了无机盐的产生,同时提高了产品质量与收率。本合成工艺乙酰半胱氨酸液相纯度达99.89%,收率84.32%,炽灼残渣为0.06%,产品质量良好。该工艺全程秉持安全、环保和卫生观念,使用水作为溶剂,具有除杂效果好、操作简单、反应条件温和、产品纯度好和收率高特点,适合工业化生产。The synthesis of acetylcysteamine is generally carried out under alkaline conditions.It affects the N-acetyl-L-cysteine’s yield because the raw L-cysteine is unstable under these conditions.We reported the optimized synthesis process of acetylcysteine.The acetylation reaction was carried out under nearly neutral condition,which greatly reduced the generation of inorganic salts,and improved the product quality and yield.The liquid phase purity of acetyl cysteine was 99.89%,the yield was 84.32%and the burning residue was 0.06%.The whole process adhere to the concept of safety,environmental protection,health,the whole process using water as a solvent,with good impurity removal effect,simple operation,mild reaction conditions,good product purity,high yield,suitable for industrial production.

关 键 词：乙酰半胱氨酸 合成 工业化 酰化 原料药 

分 类 号：TQ463[化学工程—制药化工]