Effect of heparin on recurrent IVF-ET failure patients  

作　　者：Maryam Shirmohamadi Mehri Mashayekhy Iraj Alipourfard Javad Fazeli Nasrin Ghasemi 

机构地区：[1]Department of Medical Genetics,Shahid Sadoughi University of Medical Sciences,Yazd,Iran [2]Department of Pharmacognosy,Faculty of Pharmacy and Pharmaceutical Sciences Research Center,Shahid Sadoughi University of Medical Sciences,Yazd,Iran [3]Department of Endocrinology and Female Infertility,Reproductive Biomedicine Research Center,Royan Institute for Reproductive Biomedicine,ACECR,Tehran,Iran [4]Institute of Biology,Biotechnology and Environmental Protection,Faculty of Natural Sciences,University of Silesia,Katowice,Poland [5]Abortion Research Center,Yazd Reproductive Sciences Institue,Shahid Sadoughi University of Medical Sciences,Yazd,Iran

出　　处：《Asian pacific Journal of Reproduction》2023年第2期64-70,共7页亚太生殖杂志（英文版）

摘　　要：Objective:To elucidate the possible role of unfractionated heparin in patients with failed repeated in in vitro fertilization and embryo transfer(IVF-ET)and thrombophilia.Methods:This case control study evaluated the efficacy of the unfractionated heparin in increasing the pregnancy and implantation ratio in women with recurrent IVF-ET failures.Eighty-six women received in vitro fertilization/intracytoplasmic sperm injection(IVF/ICSI)with a record of three or more previous IVF-ET failures.Participants were randomly distributed into two groups.Group A(n=43)received unfractionated heparin 5000 IU twice daily,and group B(n=43)did not take any antithrombotic drugs.Coagulation abnormalities such as factor桋Leiden(FVL)mutation,methylene tetra hydro folate reductase(MTHFR)mutation and prothrombin mutation(F栻)were evaluated.Age,body mass index,basal follicular stimulating hormone,basal estradiol,duration of infertility,and number of IVF-ET failures were compared between two groups.Results:45.0%and 17.4%of women were pregnant with and without MTHFR and prothrombin mutation,respectively,when they received unfractionated heparin treatment.The implantation rate was more in group A(12.5%)than group B(4.3%)and differences in the fertilization rate of the two groups were observed(27.7%vs.35.9%).The clinical pregnancy rate per cycle was remarkably more in group A(30.2%)than group B(14.0%).Conclusions:Heparin is a safe and valuable treatment for patients with repeated IVF-ET failures.The clinical pregnancy and implantation rates are higher in the heparin-treated group in contrast with the control group.

关 键 词：HEPARIN Recurrent implantation failure THROMBOPHILIA MTHFR C677T Prothrombin A20210G FactorⅤLeiden 

分 类 号：R714.8[医药卫生—妇产科学]