茯茶山楂降脂含片的制备工艺及其降脂作用研究  

Study on the technology of making fuzhuan tea fructus crataegi tablet and its effects on lowering lipids

作　　者：孙颖 王慧[1] 杨文娟[1] 李楠[1] 郝雨 周成东 杨盼 SUN Ying;WANG Hui;YANG Wen-juan;LI Nan;HAO Yu;ZHOU Cheng-dong;YANG Pan(School of Food Science and Engineering,Shaanxi University of Science&Technology,Xi′an 710021,China)

机构地区：[1]陕西科技大学食品科学与工程学院,陕西西安710021

出　　处：《陕西科技大学学报》2023年第2期51-58,共8页Journal of Shaanxi University of Science & Technology

基　　金：陕西省科技厅科技计划-农业领域项目(2022NY-035);陕西省西安市科技计划项目(20NYYF0022,22NYYF048);陕西省西安市未央区科技计划项目(202040);陕西科技大学博士科研启动基金项目(2022BJ-29)。

摘　　要：以茯茶多糖和山楂提取物为主要原料,采用压片法制备茯茶山楂降脂含片.通过预实验、体外降脂实验和正交试验筛选主辅料配比;以片剂外观、口感、硬度和崩解时限作为综合评分指标对配方进行综合评价,筛选出茯茶山楂降脂含片的最佳配方为:主药用量为15%(山楂∶茯茶=4∶1),填充剂用量为70%(可溶性淀粉∶甘露醇=1∶3),粘合剂为5%PEG6000和50%乙醇溶液,PVPP用量为10%,硬脂酸镁用量为0.8%,矫味剂用量为3%(山梨糖醇∶柠檬酸=2∶1).结果表明,产品的崩解时限均大于10 min,感官评价良好,茯茶山楂降脂含片对HepG2细胞的降脂和抗氧化作用良好,为降脂产品的开发与工业化生产提供一定的理论依据和数据支持.With Fuzhuan Tea polysaccharide and Fructus Crataegi extract as the primary raw ingredients,tablet pressing was used to create a lipid-lowering buccal tablet of Fuzhuan Tea and Fructus Crataegi.Using a preliminary experiment,an in vitro lipid-lowering experiment,a single factor test,and an orthogonal test,the quantities of active and auxiliary substances were evaluated.The formulation was evaluated using the appearance,taste,hardness,and dissolution time of the tablets as comprehensive scoring indexes,and the optimal formulation was identified as follows:15%of the active ingredient(Fructus Crataegi∶Poria tea=4∶1),70%of the filler(soluble starch∶mannitol=1∶3),5%PEG600050%ethanol solution as the binder,10%PVPP,and 0.8%magnesium stearate.The concentration of flavoring ingredient was 3%(sorbitol∶citric acid=2∶1).The results showed that the disintegration duration of the goods exceeded 10 minutes,and the sensory rating was favorable.Fuzhuan Tea Fructus Crataegi Lipid-lowering buccal tablets showed that they lowered lipids and acted as antioxidants in a good way on HepG2 cells.This gives a theoretical basis and real-world evidence for the development and mass production of lipid-lowering products.

关 键 词：茯茶多糖 山楂提取物 含片配方 降脂作用 

分 类 号：TS272[农业科学—茶叶生产加工]