重症监护病房获得性肌无力研究进展  

Research progress of intensive care unit-acquired weakness

作　　者：李璐 王洪霞[1] 俞立强[1] 方琪[1] LI Lu;WANG Hongxia;YU Liqiang;FANG Qi(Department of Neurology,the First Affiliated Hospital of Soochow University,Suzhou,Jiangsu,215006;Department of Electrophysiology,Weihai Municipal Hospital of Shandong Province,Weihai,Shandong,264200)

机构地区：[1]苏州大学附属第一医院神经内科,江苏苏州215006 [2]山东省威海市立医院电生理科,山东威海264200

出　　处：《实用临床医药杂志》2023年第3期134-139,共6页Journal of Clinical Medicine in Practice

基　　金：国家自然科学基金面上项目(82071300);苏州市姑苏卫生人才计划培养项目(GSWS2020002);苏州市引进临床医学团队项目(SZYJTD201802)。

摘　　要：重症监护病房获得性肌无力(ICUAW)是发生于ICU患者的危重疾病,常累及肢体肌肉及呼吸肌,导致患者脱机困难、住院时间延长及病死率增高,严重影响ICU患者预后。机械通气、脓毒血症、多脏器功能衰竭及全身炎症反应综合征(SIRS)是ICUAW常见致病原因;肠外营养、神经肌肉阻滞剂及大剂量糖皮质激素的使用、制动等也可引起ICUAW。目前,尚无ICUAW早期诊断的金标准及治疗策略。本文就ICUAW相关研究进展进行综述,以期加深临床对ICUAW的认识,并提高临床医生的诊疗能力。Intensive care unit acquired weakness(ICUAW)is a critical disease in patients in the ICU.ICUAW often involves limb muscles and respiratory muscles,resulting in difficulty in offline difficulties,prolonged hospital stay and increased mortality,which seriously affects the prognosis of patients in the ICU.Mechanical ventilation,sepsis,multiple organ failure and systemic inflammatory response syndrome(SIRS)were the common causes of ICUAW.Parenteral nutrition,neuromuscular blockers and the use of large amounts of corticosteroids,braking,etc.,can also cause ICUAW.At present,there is no golden standard and treatment strategy for early diagnosis of ICUAW.This paper reviewed the research progress of ICUAW in order to deepen the clinical understanding of ICUAW and improve the diagnosis and treatment ability of clinicians.

关 键 词：重症监护病房获得性肌无力 危重病性多发性神经病 神经电生理 神经肌肉超声 细胞因子 动物模型 

分 类 号：R746.1[医药卫生—神经病学与精神病学] Q81[医药卫生—临床医学]