多模式成像在中心性浆液性脉络膜视网膜病变中的预后生物学标志  

Prognostic biomarkers of multimodal imaging in central serous chorioretinopathy

作　　者：张琛 杨桢[1,2] 赵易[1,2] 杨小丽 ZHANG Chen;YANG Zhen;ZHAO Yi;YANG Xiaoli(Department of Ophthalmology,Affiliated Hospital of North Sichuan Medical College,Nanchong,Sichuan,637000;Department of Optometr,North Sichuan Medical College,Nanchong,Sichuan,637000)

机构地区：[1]川北医学院附属医院眼科,四川南充637000 [2]川北医学院眼视光学院,四川南充637000

出　　处：《实用临床医药杂志》2023年第4期133-137,143,共6页Journal of Clinical Medicine in Practice

基　　金：四川省南充市科学技术局2019年市校合作科研专项资金立项项目(19SXHZ0075)。

摘　　要：中心性浆液性脉络膜视网膜病变(CSC)是一种主要影响青中年男性视力的常见疾病,以黄斑区浆液性视网膜脱离为特征。虽然大部分CSC可以自发消退,但复发率较高,容易转变为慢性形式,导致视网膜色素上皮层和感光细胞的永久性损伤,从而引发不可逆的长期视力障碍,严重影响患者生活质量。由于CSC的病因不明以及临床特征多样性,目前尚无统一的分类及治疗方法。眼底自发荧光、荧光素血管造影、吲哚菁绿血管造影、光学相干断层扫描、光学相干断层扫描造影在内的多模式成像技术能够系统地描述CSC的预后,若联合机器学习技术可以提高临床效率。本文旨在将采用多模式成像对CSC的预后生物学标志物进行全面归纳和总结,更系统地评估患者预后和治疗反应,以便更好地指导临床选择治疗方案。Central serous chorioretinopathy(CSC)is a common disease that mainly affects central vision in young and middle⁃aged man,characterized by macular serous detachment.Although most of them can spontaneously subside,they have a high recurrence rate and are easy to evolve into chronic forms,resulting in permanent damage to the pigment cortex and photoreceptor cells of the retina,lead⁃ing to irreversible long⁃term visual impairment and seriously affecting the quality of life of patients.Due to the unknown etiology of CSC and the diversity of clinical features,there is no unified classification and treatment method.Multimodal imaging techniques including fundus autofluorescence,fluorescein angiography,indocyanine green angiography,optical coherence tomography,and optical coher⁃ence tomography angiography have more systematically described the prognosis of CSC,their combination with machine learning technology can improve clinical efficiency.The purpose of this study was to comprehensively summarize prognostic biomarkers of CSC by using multi⁃mode imaging,so as to evaluate patients'prognosis and treatment response more systematically,thereby better guiding clinical treatment selection.

关 键 词：中心性浆液性脉络膜视网膜病变 多模式成像 生物学标志 视力 

分 类 号：R773.4[医药卫生—眼科] R816.1[医药卫生—临床医学]