围绝经妇女甲状腺癌患者性激素水平表达情况及其临床意义  

Analysis of the expression of sex hormones in perimenopausal women with thyroid cancer and its clinical significance

作　　者：李念 李静文[1] 张慧莉[1] 陈玉环[1] 杨晓红[1] Li Nian;Li Jingwen;Zhang Huili;Chen Yuhuan;Yang Xiaohong(Department of Gynecology,Xiaogan Central Hospital,Xiaogan 432100,China)

机构地区：[1]孝感市中心医院妇科,湖北孝感432100

出　　处：《实用妇科内分泌电子杂志》2022年第27期1-3,共3页Electronic Journal of Practical Gynecological Endocrinology

基　　金：湖北省孝感市自然科学计划项目(编号XGKJ2020010033);湖北省卫生健康科研基金资助(编号WJ2019F122)

摘　　要：目的探讨围绝经妇女甲状腺癌患者性激素水平表达情况及其临床意义。方法选择65例围绝经妇女甲状腺癌患者为研究组,选择同期50例健康人为对照组。分析血清促卵泡激素(FSH)、促黄体生成素(LH)、泌乳素、雌二醇(E_(2))、孕酮(P)、睾酮(T)水平变化情况及其诊断价值。结果研究组患者血清FSH、LH及泌乳素水平低于对照组,血清E_(2)、P、T水平高于对照组,差异有统计学意义(P<0.05)。Ⅰ-Ⅱ期患者血清FSH、LH及泌乳素水平高于Ⅲ、Ⅳ期患者,Ⅲ期血清FSH、LH及泌乳素水平高于Ⅳ期患者,Ⅰ~Ⅱ期患者血清E_(2)、P、T水平低于Ⅲ、Ⅳ期患者,Ⅲ期血清E_(2)、P、T水平低于Ⅳ期患者,差异均有统计学意义(P<0.05)。受试者工作特征曲线(ROC)结果显示,FSH、LH、泌乳素、E_(2)、P、T预测围绝经妇女甲状腺癌的曲线下面积(AUC)分别为0.647、0.691、0.850、0.701、0.791、0.815,最佳临界值分别为为22.46 U/L、13.86 IU/L,2.69 nmol/L,16.54 nmol/L,1.98 nmol/L,2.16 nmol/L。结论围绝经妇女甲状腺癌患者血清性激素表达异常,与临床分期之间关系密切,在围绝经妇女甲状腺癌患者中有一定的诊断价值。Objective To investigate the expression of sex honnone levels in perimenopausal women with thyroid cancer and its clinical significance.Methods A total of 65 perimenopausal women with thyroid cancer were selected as study group and 50 healthy women were selected as control group.The changes of serum levels of follicle stimulating hormone(FSH),luteinizing hormone(LH),prolactin,estradiol(E_(2)),progesterone(P),testosterone(T)and their diagnostic value were analyzed.Results The levels of serum FSH,LH and prolactin in the study group were lower than those in the control group,while the levels of serum E_(2),P and T were higher than those in the control group,the difference was statistically significant(P<0.05).Serum levels of FSH,LH and prolactin in patients with stage Ⅰ to Ⅱ were higher than those in patients with stage Ⅲ and Ⅳ;serum levels of FSH,LH and prolactin in patients with stage IH were higher than those in patients with stage IV;serum levels of E_(2),P and T in patients with stage Ⅰ to Ⅱ were lower than those in patients with stage HI,and serum levels of E_(2),P and T in patients with stage Ⅲ were lower than those in patients with stage Ⅳ,and the differences were statistically significant(P<0.05).Receiver operating characteristic curve(ROC)results showed that the area under the curve(AUC)of FSH,LH,prolactin,E_(2),P and T for predicting thyroid cancer in perimenopausal women were 0.647,0.691,0.850,0.701,0.791 and 0.815,respectively.The optimal critical values were 22.46 U/L,13.86 IU/L,2.69 nmol/L,16.54 nmol/L,1.98 nmol/L and 2.16 nmol/L,respectively.Conclusion Abnormal serum sex hormone expression in perimenopausal women with thyroid cancer is closely related to clinical stage,which has certain diagnostic value in perimenopenopausal women with thyroid cancer.

关 键 词：围绝经 妇女 甲状腺癌 性激素 临床意义 

分 类 号：R736.1[医药卫生—肿瘤]