丙戊酸钠联合左乙拉西坦或拉莫三嗪治疗癫痫的临床效果分析  

Analysis of clinical effect of sodium valproate combined with levetiracetam or lamotrigine in the treatment of epilepsy

作　　者：周传义 陈婷婷 ZHOU Chuan-yi;CHEN Ting-ting(Department of Neurology,Liaocheng Fourth People's Hospital,Liaocheng 252000,China)

机构地区：[1]聊城市第四人民医院神经内科,252000

出　　处：《中国实用医药》2023年第5期54-57,共4页China Practical Medicine

摘　　要：目的观察采用丙戊酸钠联合左乙拉西坦或拉莫三嗪治疗癫痫患者的临床效果。方法90例癫痫患者,经系统抽样分为实验1组、实验2组、对照组,每组30例。对照组患者采用丙戊酸钠治疗,实验1组患者采用丙戊酸钠联合左乙拉西坦治疗,实验2组患者采用丙戊酸钠联合拉莫三嗪治疗。比较三组的脑电图效果、认知功能、生活质量评分。结果实验1组、实验2组患者脑电图总有效率分别为96.67%、93.33%,均高于对照组的70.00%,差异具有统计学意义(P<0.05)。治疗后,实验1组、实验2组患者认知功能评分分别为(78.23±9.13)、(76.29±9.05)分,均高于对照组的(65.14±8.29)分,差异具有统计学意义(P<0.05)。治疗后,实验1组患者心理功能评分为(83.76±4.28)分、物质生活状态评分为(81.61±4.15)分、社会功能评分为(80.13±3.24)分,实验2组患者心理功能评分为(84.16±5.33)分、物质生活状态评分为(82.28±4.61)分、社会功能评分为(79.16±4.33)分,均高于对照组的(72.37±4.64)、(73.13±4.62)、(68.92±3.13)分,差异具有统计学意义(P<0.05)。结论与单用丙戊酸钠相比,丙戊酸钠联合左乙拉西坦或拉莫三嗪治疗癫痫患者的效果更好,不仅能够明显缓解患者的临床症状,也能有效改善其认知情况,生活质量更高,值得临床推广应用。Objective To observe the clinical effect of sodium valproate combined with levetiracetam or lamotrigine in the treatment of epilepsy.Methods A total of 90 patients with epilepsy were divided into experimental group 1,experimental group 2 and control group by systematic sampling,with 30 patients in each group.Patients in the control group were treated with sodium valproate,patients in the experimental group 1 were treated with sodium valproate and levetiracetam,and patients in the experimental group 2 were treated with sodium valproate and lamotrigine.The electroencephalogram effect,cognitive function and quality of life score of the three groups were compared.Results The total effective rate of electroencephalogram in experimental group 1 and experimental group 2 were 96.67%and 93.33%,which was higher than 70.00%in the control group,and the difference was statistically significant(P<0.05).After treatment,the scores of cognitive function in experimental group 1 and experimental group 2 were(78.23±9.13)and(76.29±9.05)points,which were higher than(65.14±8.29)points in the control group,and the difference was statistically significant(P<0.05).After treatment,the scores of psychological function,material life status and social function of patients in experimental group 1 were(83.76±4.28),(81.61±4.15)and(80.13±3.24)points,and those in experimental group 2 were(84.16±5.33),(82.28±4.61)and(79.16±4.33)points,which were higher than(72.37±4.64),(73.13±4.62)and(68.92±3.13)points in the control group,and the differences were statistically significant(P<0.05).Conclusion Compared with sodium valproate alone,sodium valproate combined with levetiracetam or lamotrigine has a better effect in the treatment of epileptic patients.It can not only significantly relieve the clinical symptoms of patients,but also effectively improve their cognitive status,and have a higher quality of life,which is worthy of clinical promotion and application.

关 键 词：丙戊酸钠 左乙拉西坦 拉莫三嗪 癫痫 脑电图 

分 类 号：R742.1[医药卫生—神经病学与精神病学]