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作 者:Yingbo Yang Zhuzhen Han Tong Tian Qi Liao Jiaran Geng Ying Xiao
机构地区:[1]The SATCM Key Laboratory for New Resources&Quality Evaluation of Chinese Medicine,Institute of Chinese Materia Medica,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China [2]Jiangsu Kanion Pharmaceutical Co.,Ltd.,Lianyungang 222000,China
出 处:《Chinese Herbal Medicines》2023年第1期151-154,共4页中草药(英文版)
基 金:financial supports from the National Natural Science Foundation of China (32170402, 81703682, 81874335)。
摘 要:Objective: To study the chemical constituents from the aerial parts of Scoparia dulcis.Methods: Various chromatographic techniques were used to separate the constituents and their structures were elucidated using spectroscopic methods and by comparing their data to those reported in the literatures. The α-glucosidase inhibitory activity assay was used to identify potential α-glucosidase inhibitors.Results: Nine compounds were isolated from the aerial parts of S. dulcis. Their structures were identified as Scoparic zolone(1),(2S)-2,7-dihydroxy-2H-1,4-benzoxazin-3(4H)-one(2),(2R)-7-hydroxy-2H-1,4-benzoxazin-3(4H)-one-2-O-β-D-glucopyranoside(3),(2R)-7-methoxy-2H-1,4-benzoxazin-3(4H)-one-2-O-β-D-glucopyranoside(4),(2S)-7-hydroxy-2H-1,4-benzoxazin-3(4H)-one-2-O-β-D-glucopyranoside(5),6-methoxy-benzoxazolin-2(3H)-one(6), 4-acetonyl-3,5-dimethoxy-p-quinol(7), zizyvoside I(8), and3,4-dihydroxy benzeneacetic acid(9). Compound 2 showed the potent α-glucosidase inhibitory activity with an IC50value of(132.8 ± 11.5) μmol/L, which is 28-fold higher than the positive control acarbose.Conclusion: Compound 1 is a new natural product. Compounds 2 and 9 have not been reported in Scoparia before. Compounds 3, 5, 7, 8 are isolated from Scrophulariaceae for the first time.
关 键 词:ALKALOIDS chemical constituents α-glucosidase inhibitory activity Scoparia dulcis L.
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