复发性交界性卵巢肿瘤患者双附件切除后完成活产1例病例报道  

A case report of completed live birth after bilateral adnexal resection for patients with recurrent borderline ovarian tumors

作　　者：刘艳丽[1] 申峻涵 邝义会 李嘉恒[1] 杜姗姗 李静[1] 郜翔[2] 管一春[1] Liu Yanli;Shen Junhan;Kuang Yihui;Li Jiaheng;Du Shanshan;Li Jing;Gao Xiang;Guan Yichun(Reproductive Center of the Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China;Department of Obstetrics and Gynecology,the Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]郑州大学第三附属医院生殖中心,郑州450000 [2]郑州大学第三附属医院妇产科,郑州450000

出　　处：《中华生殖与避孕杂志》2023年第2期158-163,共6页Chinese Journal of Reproduction and Contraception

基　　金：河南省医学科技攻关计划联合共建项目(2018020181);河南省科技攻关项目(222102310329);河南省中青年卫生健康科技创新领军人才培养项目(YXKC2021020);国家卫生健康委科学研究基金河南省医学科技攻关计划省部共建项目(SBGJ202102180);国家重点研发计划(2021YFC2700602)。

摘　　要：目的探讨复发性交界性卵巢肿瘤患者保留生育力的手术方法和辅助生殖技术助孕策略。方法回顾性分析1例复发性交界性卵巢肿瘤患者的病例资料。该患者因双侧卵巢复发性交界性肿瘤,多次入院治疗行右附件切除术和左附件囊肿剥除术。患者未避孕3年未孕,考虑该患者强烈的生育需求,采用微刺激方案进行促排卵治疗,辅助生殖技术助孕过程中左侧卵巢肿瘤显著增大,随后行腹腔镜下左附件切除术,选取健康的卵巢皮质冷冻保存,以保留生育能力。结果患者共经历了5次控制性促排卵,形成了7枚可利用胚胎。患者于第3次冻胚周期移植获得成功妊娠,并分娩一活婴。患者尚有2枚胚胎和3片卵巢组织冻存。结论年轻且有生育需求的交界性卵巢肿瘤患者,可实施保留生育能力的手术和辅助生殖技术助孕,虽在一定程度上可能会导致疾病复发风险提高,但并不影响患者的生存质量,且使得患者的生育愿望得到实现。Objective To explore surgical approaches to preserve fertility and assisted reproductive technology strategies for pregnancy in patients with recurrent borderline ovarian tumors.Methods A case of recurrent borderline ovarian tumor was retrospectively analyzed.The patient was admitted several times and underwent right adnexectomy and cysts debulking in the left ovary for recurrent borderline tumors.The patient was infertile for 3 years without contraception.Considering the patient's strong desire for childbearing,ovulation treatment was performed with a microstimulation protocol.The left ovarian tumor enlarged significantly during the process of assisted reproductive technology for pregnancy assistance,left oophorectomy was carried by laparoscopic and healthy ovarian cortex was frozen to preserve fertility.Results The patient underwent 5 times of controlled ovulation cycles,acquired 7 available embryos.The patient had a successful pregnancy and delivered a live baby on the third frozen embryo cycle transfer.The patient still had 2 embryos and 3 pieces of ovarian tissue frozen.Conclusion Patients with borderline ovarian tumors who are young and have fertility needs can undergo fertility preserving surgery and assisted reproductive technology to help them get pregnant,which may lead to a higher risk of disease recurrence to a certain extent,but it does not affect the quality of patients'survival and allows the patient to achieve her fertility aspirations.

关 键 词：卵巢肿瘤 低温保存 生育力保存 交界性卵巢肿瘤 胚胎冷冻 卵巢组织冷冻 

分 类 号：R737.31[医药卫生—肿瘤]