Vitamin D therapy in pediatric patients with inflammatory bowel disease:a systematic review and meta-analysis  

作　　者：Mohammad Hassan Sohouli Fatemeh Farahmand Hosein Alimadadi Parisa Rahmani Farzaneh Motamed Elma Izze da Silva Magalhaes Pejman Rohani 

机构地区：[1]Pediatric Gastroenterology and Hepatology Research Center,Pediatrics Centre of Excellence,Children's Medical Center,Tehran University of Medical Sciences,Tehran,Iran [2]Department of Clinical Nutrition and Dietetics,Faculty of Nutrition and Food Technology,Shahid Beheshti University of Medical Sciences,Tehran,Iran [3]Postgraduate Programme in Collective Health,Federal University of Maranhao,Rua Barao de Itapary,155,Centro,Sao Luís,MA,Brazil [4]Pediatrics Gastroenterology,Department of Pediatrics,School of Medicine,Children's Medical Center,Tehran University of Medical Sciences,Tehran,Iran

出　　处：《World Journal of Pediatrics》2023年第1期48-57,共10页世界儿科杂志（英文版）

基　　金：This research was supported by grant No.1401-1-249-57731 from the Tehran University of Medical Sciences.

摘　　要：Background There is some evidence for the role of vitamin D deficiency in the pathogenesis of inflammatory bowel disease(IBD)in the pediatric population.However,the results are contradictory.Therefore,we have conducted a systematic review and meta-analysis to evaluated the effect of vitamin D on pediatric patients with IBD.Methods We carried out a systematic search in databases from inception until 20 January 2022.We included all relevant articles that evaluate the efficacy and safety of vitamin D on disease activity,inflammatory factors,and vitamin D and calcium levels in pediatric patients with IBD.Random effects models were used to combine the data.The main outcomes were then analyzed using weight mean difference(WMD)and respective 95%confidence interval(CI).Results Fifteen treatment arms met the eligibility criteria and were included.Pooled estimates indicated that intervention with vitamin D has a significantly beneficial effect on 25-hydroxy vitamin D3[25(OH)D3](pooled WMD of 17.662 ng/mL;CI 9.77-25.46;P<0.001),calcium(pooled WMD of 0.17 mg/dL;CI 0.04-0.30;P=0.009),and inflammatory factors including C-reactive protein(CRP)(pooled WMD of-6.57 mg/L;CI-11.47 to-1.67;P=0.009)and erythrocyte sedimentation rate(ESR)(pooled WMD of-7.94 mm/h;CI-12.65 to-3.22;P=0.001)levels.In addition,this effect was greater for vitamin D levels at doses greater than 2000 IU,and when follow-up duration was more than 12 weeks.Conclusion This study showed that vitamin D therapy can have a significant and beneficial effect on 25(OH)D3,calcium,and inflammatory factors in children and adolescents with IBD.

关 键 词：Disease activity index INFLAMMATION META-ANALYSIS IBD PEDIATRIC Vitamin D 

分 类 号：R725.7[医药卫生—儿科]