Effect of minocycline and its nano-formulation on central auditory system in blast-induced hearing loss rat model  

作　　者：Venkatesan Perumal Arun Reddy Ravula Ningning Shao Namas Chandra 

机构地区：[1]Center for Injury Biomechanics,Materials,and Medicine,Department of Biomedical Engineering,New Jersey Institute of Technology,Newark,NJ,07102,USA

出　　处：《Journal of Otology》2023年第1期38-48,共11页中华耳科学杂志（英文版）

基　　金：funding provided by Faculty seed grant (FSG) from NJIT, Newark, USA " (NC and Venkatesan Perumal).

摘　　要：Blast injuries are common among the military service members and veterans.One of the devastating effects of blast wave induced TBI is either temporary or permanent hearing loss.Treating hearing loss using minocycline is restricted by optimal drug concentration,route of administration,and its half-life.Therefore,therapeutic approach using novel therapeutic delivery method is in great need.Among the different delivery methods,nanotechnology-based drug delivery is desirable,which can achieve longer systemic circulation,pass through some biological barriers and specifically targets desired sites.The current study aimed to examine therapeutic effect of minocycline and its nanoparticle formulation in moderate blast induced hearing loss rat model through central auditory system.The I.v.administered nanoparticle at reduced dose and frequency than regularly administered toxic dose.After moderate blast exposure,rats had hearing impairment as determined by ABR at 7-and 30-days post exposure.In chronic condition,free minocycline also showed the significant reduction in ABR threshold.In central auditory system,it is found in this study that minocycline nanoparticles ameliorate excitation in inferior colliculus;and astrocytes and microglia activation after the blast exposure is reduced by minocycline nanoparticles administration.The study demonstrated that in moderate blast induced hearing loss,minocycline and its nanoparticle formulation exhibited the optimal therapeutic effect on the recovery of the ABR impairment and a protective effect through central auditory system.In conclusion,targeted and non-targeted nanoparticle formulation have therapeutic effect on blast induced hearing loss.

关 键 词：MINOCYCLINE NANOPARTICLE Hearing loss Blast injury and targeted drug delivery 

分 类 号：R764[医药卫生—耳鼻咽喉科]