MINOCYCLINE

作品数:53被引量:160H指数:8
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相关作者:李海龙晏勇张岩王苹姜文敏更多>>
相关机构:第二军医大学复旦大学重庆医科大学附属第一医院空军军医大学(第四军医大学)更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划上海市科委实验动物专项重庆市自然科学基金更多>>
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Efficacy and safety of minocycline in retinitis pigmentosa:a prospective,open-label,single-arm trial
《Signal Transduction and Targeted Therapy》2025年第1期271-277,共7页Yuxi Chen Yuan Pan Yanyan Xie Yuxun Shi Yao Lu Yiwen Xia Wenru Su Xiaoqing Chen Zuoyi Li Minzhen Wang Siyu Miao Yating Yang Chenjin Jin Guangwei Luo Shixian Long Hui Xiao Chuangxin Huang Jian Zhang Dan Liang 
supported by the Sun Yat-sen University Clinical Research 5010 Program(2018012).
Retinitis pigmentosa(RP)is characterized by progressive photoreceptor cells death accelerated by the proliferation and activation of microglia pathologically.No consensus exists on the treatment.Minocycline is recogni...
关键词:protective PROSPECTIVE adapted 
Minocycline in the eradication of Helicobacter pylori infection: A systematic review and meta-analysis被引量:1
《World Journal of Gastroenterology》2024年第17期2354-2368,共15页Kai Zhou Cai-Ling Li Hua Zhang Bao-Jun Suo Yu-Xin Zhang Xin-Lu Ren Yu-Xin Wang Chang-Min Mi Ling-Ling Ma Li-Ya Zhou Xue-Li Tian Zhi-Qiang Song 
Supported by National Natural Science Foundation of China,No.82170562;Beijing Natural Science Foundation,No.7232199;Capital’s Funds for Health Improvement and Research,No.2022-2-4093;Youth Incubation Fund of Peking University Third Hospital,No.BYSYFY2021003;Key Laboratory for Helicobacter pylori Infection and Upper Gastrointestinal Diseases in Beijing,No.BZ0371.
BACKGROUND Difficulty in obtaining tetracycline,increased adverse reactions,and relatively complicated medication methods have limited the clinical application of the classic bismuth quadruple therapy.Therefore,the se...
关键词:Helicobacter pylori MINOCYCLINE ERADICATION Safety RESISTANCE 
Morbihan disease misdiagnosed as senile blepharoptosis and successfully treated with short-term minocycline and ketotifen: A case report
《World Journal of Clinical Cases》2023年第19期4692-4697,共6页Jun Na Yan Wu 
BACKGROUND Morbihan disease is a rare skin condition with diagnostic and therapeutic challenges.Facial nonpitting erythematous edema is usually considered to be a characteristic manifestation and diagnostic clue for t...
关键词:Morbihan disease PTOSIS MINOCYCLINE Mast cells Treatment Case report 
Up-regulation of microglial chemokine CXCL12 in anterior cingulate cortex mediates neuropathic pain in diabetic mice被引量:2
《Acta Pharmacologica Sinica》2023年第7期1337-1349,共13页Zi-hua Song Xiang-Jie Song Chen-ling Yang Peng Cao Yu Mao Yan Jin Meng-yun Xu Hai-tao Wang Xia Zhu Wei Wang Zhi Zhang Wen-juan Tao 
the National Natural Science Foundation of China(grants 32025017,32121002,81971264,and 32271176);CAS Project for Young Scientists in Basic Research(YSBR-013);Natural Science Foundation of Anhui Province(KJ2020A0138).
Diabetic patients frequently experience neuropathic pain,which currently lacks effective treatments.The mechanisms underlying diabetic neuropathic pain remain unclear.The anterior cingulate cortex(ACC)is well-known to...
关键词:diabetic neuropathic pain anterior cingulate cortex MICROGLIA glutamatergic neurons microglia-neuron communication CXCL12/CXCR4 signaling MINOCYCLINE AMD3100 
Effect of minocycline and its nano-formulation on central auditory system in blast-induced hearing loss rat model被引量:1
《Journal of Otology》2023年第1期38-48,共11页Venkatesan Perumal Arun Reddy Ravula Ningning Shao Namas Chandra 
funding provided by Faculty seed grant (FSG) from NJIT, Newark, USA " (NC and Venkatesan Perumal).
Blast injuries are common among the military service members and veterans.One of the devastating effects of blast wave induced TBI is either temporary or permanent hearing loss.Treating hearing loss using minocycline ...
关键词:MINOCYCLINE NANOPARTICLE Hearing loss Blast injury and targeted drug delivery 
Better together? Treating traumatic brain injury with minocycline plus N-acetylcysteine
《Neural Regeneration Research》2022年第12期2589-2592,共4页Siobhán Lawless Peter J.Bergold 
funded by an award “Minocycline plus N-acetylcysteine improves brain structure and function after experimental brain injury with clinically useful time window”(NS108190) to PJB
Traumatic brain injury has a complex pathophysiology that produces both rapid and delayed brain damage. Rapid damage initiates immediately after injury. Treatment of traumatic brain injury is typically delayed many ho...
关键词:clinical trial outcome measures preclinical testing rodent models of traumatic brain injury therapeutic time window 
Minocycline Activates the Nucleus of the Solitary Tract- Associated Network to Alleviate Lipopolysaccharide-Induced Neuroinflammation
《Chinese Medical Sciences Journal》2022年第1期1-14,共14页Jianbo Xiu Lanlan Li Qi Xu 
supported by the research grants from the National Natural Science Foundation of China(81625008 and 31970952);the National Key Research and Development Program of China(2020YFA0804500,2020YFA0804502)。
Objective To examine the neuroanatomical substrates underlying the effects of minocycline in alleviating lipopolysaccharide(LPS)-induced neuroinflammation.Methods Forty C57BL/6 male mice were randomly and equally divi...
关键词:NEUROINFLAMMATION LIPOPOLYSACCHARIDE depression nucleus tractus solitaries MICROGLIA 
Macrophage membrane-mediated targeted drug delivery for treatment of spinal cord injury regardless of the macrophage polarization states被引量:4
《Asian Journal of Pharmaceutical Sciences》2021年第4期459-470,共12页Wei Tang Yi Yang Ling Yang Mei Tang Ying Chen Chong Li 
supported by the National Natural Science Foundation of China(No.81673376);the National Natural Science Foundation of Chongqing(cstc2015jcyj BX0100);the project for innovative Research Group at Higher Educational Institutions in Chongqing(CXQT20006)。
Targeted delivery of therapeutics for spinal cord injury(SCI)has been a long-term challenge due to the complexity of the pathological procession.Macrophage,as an immune cell,can selectively accumulate at the trauma si...
关键词:Spinal cord injury PYROPTOSIS Macrophage polarization MINOCYCLINE Actively targeted delivery 
Neuroprotective effects of minocycline on focal cerebral ischemia injury: a systematic review被引量:13
《Neural Regeneration Research》2020年第5期773-782,共10页Yazdan Naderi Yunes Panahi George E. Barreto Amirhosein Sahebkar 
To review the neuroprotective effects of minocycline in focal cerebral ischemia in animal models.By searching in the databases of PubMed,ScienceDirect,and Scopus,and considering the inclusion and exclusion criteria of...
关键词:ISCHEMIC STROKE MINOCYCLINE NEURONAL regeneration NEUROPROTECTION STROKE 
Clinical observation of low dose minocycline hydrochloride sustained-release agent combined with Vitapex in the treatment of invasive periodontitis
《Journal of Hainan Medical University》2020年第1期62-62,共1页Xu Zheng Jiang Pan Peng Xiao-zhi 
Medical and health science and technology innovation project of Sanya city(No.YW1323).
Objective: To study the efficacy of minocycline hydrochloride sustained-release agent combined with Vitapex in the treatment of invasive periodontitis. Method 80 patients with erosive periodontitis were randomly divid...
关键词:Low dose MINOCYCLINE HYDROCHLORIDE Relievers VITAPEX INVASIVE PERIODONTITIS 
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