Minocycline in the eradication of Helicobacter pylori infection: A systematic review and meta-analysis  

作　　者：Kai Zhou Cai-Ling Li Hua Zhang Bao-Jun Suo Yu-Xin Zhang Xin-Lu Ren Yu-Xin Wang Chang-Min Mi Ling-Ling Ma Li-Ya Zhou Xue-Li Tian Zhi-Qiang Song 

机构地区：[1]Department of Gastroenterology,Peking University Third Hospital,Beijing 100191,China

出　　处：《World Journal of Gastroenterology》2024年第17期2354-2368,共15页世界胃肠病学杂志（英文版）

基　　金：Supported by National Natural Science Foundation of China,No.82170562;Beijing Natural Science Foundation,No.7232199;Capital’s Funds for Health Improvement and Research,No.2022-2-4093;Youth Incubation Fund of Peking University Third Hospital,No.BYSYFY2021003;Key Laboratory for Helicobacter pylori Infection and Upper Gastrointestinal Diseases in Beijing,No.BZ0371.

摘　　要：BACKGROUND Difficulty in obtaining tetracycline,increased adverse reactions,and relatively complicated medication methods have limited the clinical application of the classic bismuth quadruple therapy.Therefore,the search for new alternative drugs has become one of the research hotspots.In recent years,minocycline,as a semisynthetic tetracycline,has demonstrated good potential for eradicating Helicobacter pylori(H.pylori)infection,but the systematic evaluation of its role remains lacking.AIM To explore the efficacy,safety,and compliance of minocycline in eradicating H.pylori infection.METHODS We comprehensively retrieved the electronic databases of PubMed,Embase,Web of Science,China National Knowledge Infrastructure,SinoMed,and Wanfang database as of October 30,2023,and finally included 22 research reports on H.pylori eradication with minocycline-containing regimens as per the inclusion and exclusion criteria.The eradication rates of H.pylori were calculated using a fixed or a random effect model,and the heterogeneity and publication bias of the studies were measured.RESULTS The single-arm meta-analysis revealed that the minocycline-containing regimens achieved good overall H.pylori eradication rates,reaching 82.3%[95%confidence interval(CI):79.7%-85.1%]in the intention-to-treat analysis and 90.0%(95%CI:87.7%-92.4%)in the per-protocol analysis.The overall safety and compliance of the minocycline-containing regimens were good,demonstrating an overall incidence of adverse reactions of 36.5%(95%CI:31.5%-42.2%).Further by traditional meta-analysis,the results showed that the minocycline-containing regimens were not statistically different from other commonly used eradication regimens in eradication rate and incidence of adverse effects.Most of the adverse reactions were mild to moderate and well-tolerated,and dizziness was relatively prominent in the minocycline-containing regimens(16%).CONCLUSION The minocycline-containing regimens demonstrated good efficacy,safety,and compliance in H.pylori eradication.Minocycline

关 键 词：Helicobacter pylori MINOCYCLINE ERADICATION Safety RESISTANCE 

分 类 号：R573[医药卫生—消化系统]