低氧诱导因子-1在氧诱导视网膜新生血管形成中的研究进展  

Research advance on the role of hypoxia-inducible factor-1 in oxygen-induced retinal neovascularization

作　　者：范弯弯 罗先琼[1] Fan Wanwan;Luo Xianqiong(Department of Neonatal Pediatrics,Guangdong Women and Children's Hospital,Guangzhou 511442,China)

机构地区：[1]广东省妇幼保健院新生儿科,广州511442

出　　处：《中华实用儿科临床杂志》2023年第3期230-233,共4页Chinese Journal of Applied Clinical Pediatrics

基　　金：广东省自然科学基金(2019A1515011417)。

摘　　要：低氧诱导因子-1(HIF-1)是机体内重要的转录因子,在低氧状态下介导一系列靶基因转录以适应低氧反应。氧诱导视网膜新生血管形成(RNV)是早产儿视网膜病(ROP)的重要病理过程。HIF-1可通过介导血管内皮生长因子、血管生成素、血小板衍生生长因子等的转录促进RNV,进而导致ROP,因此,HIF-1在ROP的病理过程中发挥重要作用。现总结近年来HIF-1在氧诱导RNV中的相关研究进展,以期对ROP的发病机制及治疗有更进一步认识与启发。Hypoxia-inducible factor-1(HIF-1)is an essential transcription factor,which mediates the transcription of multiple target genes to adapt the body for hypoxia.Oxygen-induced retinal neovascularization(RNV)is an important pathological process of retinopathy of prematurity(ROP).By mediating the transcription of vascular endothelial growth factors,angiopoietin and platelet-derived growth factors,HIF-1 can promote RNV and then lead to ROP.Therefore,HIF-1 plays a vital role in the pathological process of ROP.In this paper,the recent research progress on the role of HIF-1 in oxygen-induced RNV was summarized in order to further the understanding of ROP pathogenesis and treatment.

关 键 词：低氧诱导因子-1 早产儿视网膜病 氧诱导视网膜新生血管形成 

分 类 号：R774.1[医药卫生—眼科]