High-fluence relay-based disposable photoacoustic-ultrasonic endoscopy for in vivo anatomical imaging of gastrointestinal tract  

作　　者：XUE WEN PENG LEI SHENGXIN HUANG XIAOYU CHEN YANCHI YUAN DI KE RUI LIU JIAXI LIANG ERQI WANG BO WEI KEDI XIONG SIHUA YANG 

机构地区：[1]MOE Key Laboratory of Laser Life Science&Institute of Laser Life Science,South China Normal University,Guangzhou 510631,China [2]Guangdong Provincial Key Laboratory of Laser Life Science,College of Biophotonics,South China Normal University,Guangzhou 510631,China [3]Institute of Biological and Medical Engineering,Guangdong Academy of Sciences,Guangzhou 510316,China [4]Department of Gastrointestinal Surgery,Third Affiliated Hospital,Sun Yat-sen University,Guangzhou 510182,China

出　　处：《Photonics Research》2023年第1期55-64,共10页光子学研究（英文版）

基　　金：National Natural Science Foundation of China(62005084,61627827,6182250);Natural Science Foundation of Guangdong Province(2022A1515010548,2022A1515011247,2019A1515011399);Science and Technology Program of Guangzhou(202206010094,2019050001);Special Fund of Guangdong Academy of Sciences(2021GDASYL-20210103031)。

摘　　要：Photoacoustic endomicroscopy combined with ultrasound(PAEM-US)has been a long-standing expectation for gastrointestinal tumor examination.Here,we introduce a prototype disposable PAEM-US catheter and corresponding power interface unit,featuring catheter switchability,self-internal three-dimensional scanning,and system repeatability for gastrointestinal endoscopy.By utilizing high-fluence relays,cascade insertion loss of the optical waveguide is minimized to 0.6 dB with a high performance of power resistance,and a focus-customizable acousto-optic coaxial probe is designed for high-sensitivity optical-resolution photoacoustic imaging.Imaging capability was demonstrated with in vivo anatomical imaging at 30 frames per second.Imaging results showed co-registered microscopic visualization of the microvascular and stratification of the rat colorectum with lateral resolution of 18μm and axial resolution of 63μm,holding great potential in the clinical detection of gastrointestinal diseases.

关 键 词：vivo utilizing INSERTION 

分 类 号：TM58[电气工程—电器]