成人自身免疫性肠病一例  

A case of adult-onset autoimmune enteropathy

作　　者：钟巧 方亮[2] 陈琰琰 徐国斌[5] 黄梅芳[1] 赵秋[1] 肖书渊[6] 陈敏[1] Zhong Qiao;Fang Liang;Chen Yanyan;Xu Guobin;Huang Meifang;Zhao Qiu;Xiao Shuyuan;Chen Min(Department of Gastroenterology,Zhongnan Hospital,Wuhan University,Wuhan 430071,China;Huanggang Central Hospital,Huanggang 438021,China;Center for Pathology and Molecular Diagnostics,Wuhan University,Wuhan 430071,China;Department of Pathology,Zhongnan Hospital,Wuhan University,Wuhan 430071,China;Department of Radiology,Zhongnan Hospital,Wuhan University,Wuhan 430071,China;Department of Pathology,University of Chicago Medicine,Chicago 60637,USA)

机构地区：[1]武汉大学中南医院消化内科,武汉430071 [2]黄冈市中心医院,黄冈438021 [3]武汉大学病理中心,武汉430071 [4]武汉大学中南医院病理科,武汉430071 [5]武汉大学中南医院影像科,武汉430071 [6]美国芝加哥大学病理系,芝加哥60637

出　　处：《中华炎性肠病杂志（中英文）》2023年第1期90-92,共3页Chinese Journal of Inflammatory Bowel Diseases

摘　　要：本文报道武汉大学中南医院消化内科收治的1例成人自身免疫性肠病(AIE)患者,以间断腹痛伴腹泻、体质量下降为主要临床表现,实验室检查提示免疫球蛋白IgG和IgE增高,抗核抗体(ANA)阳性;内镜下可见十二指肠及回肠黏膜绒毛明显萎缩;肠道组织活检提示十二指肠绒毛萎缩,杯状细胞减少,固有层淋巴细胞浸润,回肠黏膜绒毛变平变钝;综合诊断为成人AIE,给予激素治疗有效,目前正在密切随访中。成人AIE较为罕见,总结本例患者的诊治经验有助于提高临床医生对AIE诊断及鉴别诊断的认识。This paper reports a case of adult-onset autoimmune enteropathy(AIE)diagnosed and treated at the Department of Gastroenterology in Zhongnan Hospital of Wuhan University.The patient had intermittent abdominal pain with diarrhea and weight loss as the main clinical manifestations.Laboratory examination results showed increased IgG and IgE,and positive antinuclear antibody(ANA).Obvious villous atrophy of duodenum and ileum was observed under endoscopy.The intestinal biopsy showed villous atrophy of duodenum,reduction of goblet cells,lymphocyte infiltration of the lamina propria and flattening and blunting of villous of ileum mucosa.The patient was comprehensively diagnosed as AIE.Prednisone therapy is effective and the patients is being followed up closely.Adult-onset AIE is rare.Summarizing the diagnosis and treatment experience of this patient is helpful to improve clinicians′understanding of diagnosis and differential diagnosis of AIE.

关 键 词：自身免疫性肠病 成人 慢性腹泻 绒毛萎缩 

分 类 号：R574[医药卫生—消化系统]