Elodexanthones A—J, Isoprenylated Xanthone Derivatives with Diverse Skeletons and Bioactivities from Hypericum elodeoides  

作　　者：Yanbing Mu Yaqi Li Qiji Li Wenjun Xu Yunpeng Sun Siyuan Wang Letian Cui Lingyi Kong Jun Luo 

机构地区：[1]State Key Laboratory of Naturals Medicine and Jiangsu Key Laboratory of Bioactive Natural Product Research,School of Traditional Chinese Pharmacy,China Pharmaceutical University,24 Tong Jia Xiang,Nanjing,Jiangsu,210009 China

出　　处：《Chinese Journal of Chemistry》2022年第24期2939-2946,共8页中国化学（英文版）

基　　金：supported by the National Natural Science Foundation of China(32170406);the“Double First-Class”University project(CPU2018GY08).

摘　　要：Elodexanthones A—J (1—10), two pairs of rearranged isoprenylated xanthone enantiomers with an unprecedent 6/6/5/6 tetracyclic core (1—2) along with seven new isoprenylated xanthones (3—9) and a pair of phenylpropanoid xanthones (10), were purified and enantio-separated from the whole plant of Hypericum elodeoides. Their structures including absolute configurations were characterized by the comprehensive analysis of NMR, HRESIMS, NMR calculations, and ECD calculations. Through Bayer-Villiger oxidation, Claisen condensation and electrophilic addition, the rearranged skeletons of elodexanthones A—B (1—2) were generated from isoprenylated xanthone precursors. The bioactivities evaluation exhibited that compounds 3, 5, 8—10 showed anti-inflammatory activity with the IC_(50) values in the range of 9.53—34.39 μmol/L, and compounds 3—7, and 9 showed notable α-glucosidase inhibitory activity (IC_(50): 6.02—257.11 μmol/L).

关 键 词：Hypericum eldeoides Isoprenylated xanthones Structure elucidation Biological activity INFLAMMATORY 

分 类 号：O62[理学—有机化学]