贵州省侗族、苗族地区女性绝经前后空腹血糖水平与胆石症的关系研究  

The relationship between fasting blood glucose and gallstone disease in premenopausal and postmenopausal women in Dong and Miao ethnic areas of Guizhou Province

作　　者：刘云涛 姚云骞 覃子秀 关菡 王子云[1] 洪峰[1] 曾奇兵[1] LIU Yun-tao;YAO Yun-qian;QIN Zi-xiu;GUAN Han;WANG Zi-yun;HONG Feng;ZENG Qi-bing(The Key Laboratory of Environmental Pollution Monitoring and Disease Control,Ministry of Education,School of Public Health,Guizhou Medical University,Guiyang,Guizhou 550025,China)

机构地区：[1]贵州医科大学公共卫生与健康学院,环境污染与疾病监控教育部重点实验室,贵州贵阳550025

出　　处：《现代预防医学》2023年第5期769-774,共6页Modern Preventive Medicine

基　　金：国家重点研发计划课题(2017YFC0907301);贵州省科技计划项目(黔科合平台人才[2018]5403)。

摘　　要：目的 探讨女性在绝经前后空腹血糖与胆石症之间的关系。方法 采用多阶段、整群抽样方法,对贵州省侗族、苗族地区30~79岁女性进行问卷调查、体格检查和生化指标检测。根据其空腹血糖水平,分为正常血糖组、空腹血糖受损组和糖尿病组,调查女性在绝经前后不同血糖分组中胆石症的检出率,并利用logistic回归方法计算女性绝经前后空腹血糖水平与胆石症关系的OR值和95%CI。结果 在绝经前,正常血糖组、空腹血糖受损组和糖尿病组的胆石症检出率分别为10.0%,13.4%和16.1%(P=0.124)。在绝经后,正常血糖组、空腹血糖受损组和糖尿病组的胆石症检出率分别为15.4%,23.4%和29.6%(P<0.001)。在利用logistic回归模型调整多个变量后发现,绝经前女性空腹血糖与胆石症无关联,但绝经后女性空腹血糖与胆石症的风险有关。在绝经后女性中,比较于正常血糖组,空腹血糖受损组(OR=1.354, 95%CI:1.003~1.827)和糖尿病组(OR=1.828, 95%CI:1.373~2.435)的胆石症患病风险较高。结论 绝经前女性空腹血糖与胆石症无关联,而绝经后女性高空腹血糖与胆石症的患病风险增加有关。Objective To investigate the relationship between fasting blood glucose and gallstone disease in premenopausal and postmenopausal women.Methods Using a multi-stage cluster sampling method,questionnaire interview,physical examination,and laboratory tests were conducted among Dong and Miao women aged 30 to 79 years old in Guizhou Province.The research subjects were divided into normal blood glucose group,impaired fasting blood glucose group,and diabetes group according to fasting blood glucose levels.The detection rates of gallstone disease in the three groups of premenopausal women and postmenopausal women were investigated.Logistic regression was used to calculate the OR value and 95%CI of the relationship between fasting blood glucose and gallstone disease.Results The detection rates of gallstone disease in normal blood glucose group,impaired fasting blood glucose group,and diabetes group for premenopausal women were 10.0%,13.4%,and 16.1%,respectively(P=0.124),and those for postmenopausal women were 15.4%,23.4%,and 29.6%,respectively(P<0.001).After adjusting for various potential factors,multivariate logistic regression results showed that fasting blood glucose was not associated with the risk of gallstone disease in premenopausal women,but fasting blood glucose was related to the risk of gallstone disease in postmenopausal women.Compared with normal blood glucose group,impaired fasting glucose group(OR=1.354,95%CI:1.003-1.827)and diabetes group(OR=1.828,95%CI:1.373-2.435)were at higher risk of gallstone disease for postmenopausal women.Conclusion Fasting blood glucose is associated with increased risk of gallstone disease in postmenopausal women but not in premenopausal women.

关 键 词：胆石症 空腹血糖 糖尿病 女性 绝经 

分 类 号：R575.62[医药卫生—消化系统]