甘油三酯-葡萄糖指数与胆石病患病风险关联——多中心健康体检人群研究  

The association between TyG-index and the risk of gallstone disease:a multicenter study

作　　者：李春燕 朱培 焦鹏[2] 张弛 于文倩 何明升 江果恒 李鸿钰 李诗懿 张本 王新 LI Chun-yan;ZHU Pei;JIAO Peng;ZHANG Chi;YU Wen-qian;HE Ming-sheng;JIANG Guo-heng;LI Hong-yu;LI Shi-yi;ZHANG Ben;WANG Xin(West China School of Public Health and West China Fourth Hospital,Sichuan University,Chengdu,Sichuan 610041,China;不详)

机构地区：[1]四川大学华西公共卫生学院/华西第四医院,四川成都610041 [2]济宁市第一人民医院 [3]天津医科大学肿瘤医院

出　　处：《现代预防医学》2023年第5期775-780,802,共7页Modern Preventive Medicine

基　　金：国家自然科学基金(81673255,81874283,81903398);中央高校基本科研基金(YJ2021112);中国青年专业人员招聘计划;四川省杰出青年科学基金(23NSFJQ0076);四川天府峨眉计划青年人才项目;四川省医学会医学科研青年创新课题(Q21016);四川大学基础医学推广计划和尖端学科发展计划;陆军军医大学项目(WX2015-013,2018XLC1004,SWH2018BJJJ-12);陆军军医大学第一附属医院项目(S2016ZDCX1012)。

摘　　要：目的 探索甘油三酯-葡萄糖指数(triglyceride-glucose,TyG index)与胆石病(gallstone disease, GSD)患病风险之间的关联性。方法 基于全国多中心健康体检人群队列中来自天津、山东、重庆地区5家医院2015—2020年期间参加健康体检人群,收集研究对象健康体检人口学、血生化检测、腹部超声检查结果。利用空腹血糖水平和空腹甘油三酯水平计算TyG指数,并利用四分位数对指标进行描述。在每家中心利用多因素logistic回归探讨TyG指数与胆石病患病风险之间的关联性,最后利用meta分析方法对5家中心的研究结果进行合并。结果 本研究共纳入585 071名研究对象,其中41 852人被诊断为胆石病。各中心合并研究结果汇总分析显示,与Q25相比,Q_(50)、Q_(75)、Q_(100)人群胆结石患病风险分别为2.66(95%CI:0.78~9.06;P=0.117)、2.10(95%CI:1.95~2.26;P<0.001)和2.46(95%CI:2.08~2.92;P<0.001)。TyG指数每上升1个单位和每改变1个标准差,胆石症患病风险分别上升0.25(95%CI:0.13~0.37)倍和0.24(95%CI:0.16~0.32)倍。结论 TyG指数与胆石症的患病风险相关,这可能对胆结石发病高危人群的识别提供依据。该研究结果可能为胆结石发病机制探讨提供新的视角和研究思路。Objective To explore the association between the triglyceride-glucose index(TyG)and the risk of gallstone disease(GSD).Methods Based on the national multi-center health examination cohort of people from 5 hospitals in Tianjin,Shandong,and Chongqing from 2015 to 2020,demographic information,blood biochemical examination,and abdominal ultrasound examination results were collected.TyG index was calculated by fasting blood glucose level and fasting triglyceride level,and the index was described by quartile.Multivariate logistic regression was used to explore the relationship between TyG index and the risk of cholelithiasis in each center.Finally,meta-analysis was conducted to combine the results of five centers.Results A total of 585071 subjects were included in this study,among which 41852 were diagnosed with GSD.Pooled analysis showed that compared with Q25,the risk of GSD in Q_(50)、Q_(75) and Q_(100) patients was 2.66(95%CI:0.78-9.06;P=0.117),2.10(95%CI:1.95-2.26;P<0.001)and 2.46(95%CI:2.08-2.92;P<0.001).The risk of GSD increased 0.25(95%CI:0.13-0.37)times and 0.24(95%CI:0.16-0.32)times for every 1 unit increase and 1 standard deviation change of TyG index,respectively.Conclusion TyG index is associated with the risk of GSD,which may provide evidence for the identification of high-risk groups of gallstones.This study may provide a new perspective and research insight for the pathogenesis of gallstone.

关 键 词：胆石病 TyG 胰岛素抵抗 多中心横断面研究 

分 类 号：R575.62[医药卫生—消化系统]