CYPA蛋白在恶性肿瘤中的研究进展  

Research progress of CYPA in malignant tumors

作　　者：齐之迎[1] 郭学旺 王芳[1] Qi Zhiying;Guo Xuewang;Wang Fang(Department of Gynecology,the Second Hospital of Tianjin Medical University,Tianjin 300211,China)

机构地区：[1]天津医科大学第二医院妇科,天津300211

出　　处：《国际生物医学工程杂志》2022年第4期350-355,共6页International Journal of Biomedical Engineering

基　　金：天津市科技计划项目(21JCYBJC01670)。

摘　　要：亲环蛋白A(CYPA)是亲环蛋白家族的重要成员之一,由肽基脯氨酰异构酶A基因编码,具有多种重要的生物学功能,主要参与炎症、免疫等病理生理过程。CYPA在多种恶性肿瘤如鼻咽癌、乳腺癌、肺癌、胃癌、结直肠癌、肝细胞癌、胆管癌、胰腺癌、子宫内膜癌、卵巢癌等中表达升高,且通过多种不同分子机制在肿瘤细胞增殖、侵袭、凋亡、转移、血管新生及上皮细胞-间充质转化中发挥调控作用,其中尤以CYPA与CD147的特异性结合作用得到广泛关注。主要对CYPA在多种恶性肿瘤中的作用机制进行综述,分析其在恶性肿瘤中的调控机制及潜在的干预方式,以期在未来的肿瘤早期诊断及精准治疗中发挥重要作用。Cyclosporin A(CYPA)is an important member of the cyclophilin family,encoded by the peptidyl prolyl isomerase A gene,and has a variety of important biological functions,mainly involved in inflammation,immunity,and other pathophysiological processes.In addition,CYPA plays a regulatory role in tumor cell proliferation,invasion,apoptosis,metastasis,angiogenesis,and epithelial-mesenchymal transition through various molecular mechanisms,among which the specific binding of CYPA to CD147 has received wide attention.In this review,the mechanism of CYPA in various malignant tumors was mainly reviewed,and its regulatory mechanism and potential interventions in malignant tumors were analyzed,with the aim that CYPA will play an important role in the early diagnosis and precise treatment of tumors in the future.

关 键 词：亲环蛋白A 恶性肿瘤 分子机制 早期诊断 精准治疗 

分 类 号：R730.2[医药卫生—肿瘤]