正视儿童脉络膜厚度的分布特征及相关影响因素  

Analysis of Choroidal Thickness Distribution and Related Infuencing Factors in Emmetropia Children

作　　者：黄聪聪 符爱存[1] 于世傲 马娜娜 常铭航 尚丽丽 庞雪娜 金学民[1] 雷博 孙广莉[1] Congcong Huang;Aicun Fu;Shiao Yu;Nana Ma;Minghang Chang;Lili Shang;Xuena Pang;Xuemin Jin;Bo Lei;Guangli Sun(Department of Ophthalmology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China;Henan Eye Institute,Henan Eye Hospital,Zhengzhou 450003,China)

机构地区：[1]郑州大学第一附属医院眼科,郑州450000 [2]河南省眼科研究所河南省立眼科医院,郑州450003

出　　处：《中华眼视光学与视觉科学杂志》2023年第2期125-132,共8页Chinese Journal Of Optometry Ophthalmology And Visual Science

基　　金：河南省高等学校重点科研项目(22A320024);河南省高等学校重点科研项目(19A320012)。

摘　　要：目的:应用扫频源光学相干断层扫描血流成像技术(SS-OCTA)观察正视儿童黄斑区脉络膜厚度(CHT)的分布特征,并探讨其相关影响因素。方法:横断面研究。连续性纳入2021年5—9月在郑州大学第一附属医院眼科就诊的6~12岁正视儿童63例。以黄斑中心凹为中心,使用SS-OCTA测量黄斑区的CHT和脉络膜血管指数(CVI),根据ETDRS分区将图像划分为3个环区:黄斑中心凹区(直径0~1 mm)、内环区(直径1~3 mm)和外环区(直径3~6 mm)。均纳入右眼数据分析。采用单因素方差分析比较3个环区和内、外环区的上方、颞侧、下方和鼻侧4个区域的CHT,并采用单因素线性回归和多元线性回归分析3个环区的CHT与性别、年龄、屈光度、父母屈光度、眼轴长度、瞳孔直径和CVI等参数的相关性。结果:黄斑中心凹区、内环区和外环区的CHT分别为(320±58)(315±55)(299±47)μm(F=2.77,P=0.065),外环区的CHT比黄斑中心凹区的CHT薄(t=2.20,P=0.025),其余两两环区CHT相比,差异均无统计学意义(均P>0.05)。黄斑中心凹区和内、外环区的上方、颞侧、下方及鼻侧共9个区域的CHT相比,总体差异有统计学意义(F_(不同区域)=19.20,P<0.001),在内环区和外环区的上方、颞侧、下方和鼻侧4个区域的CHT相比,差异均有统计学意义(F_(内环区)=8.15,P<0.001;F_(外环区)=43.11,P<0.001),均是鼻侧最薄。经单因素线性回归分析,黄斑中心凹区、内环区的CHT均与瞳孔直径相关(β=14.31,P=0.035;β=13.88,P=0.039);黄斑中心凹区、内环区和外环区的CHT均与对应环区的CVI相关(β=264.60、335.87、463.22,均P<0.001)。去除混杂因素后,经多因素线性回归分析发现黄斑中心凹区、内环区和外环区的CHT均与对应环区的CVI呈正相关(β=233.96、306.93、429.25,均P<0.001),其中黄斑中心凹区、内环区的CHT与瞳孔直径呈正相关(β=18.32、17.56,P=0.023、0.027);内环区和外环区的CHT与性别有相关性(β=24.92、23.50,P=0.043Objective:To explore the distribution characteristics of choroidal thickness in the macular region and its related influencing factors in emmetropia children by swept source optical coherence tomography angiography(SS-OCTA).Methods:In this cross-sectional study,63 emmetropia children aged 6-12 years old who visited department of ophthalmology,the First Affliated Hospital of Zhengzhou University from May to September 2021 were continuously included.With the macular central fovea as the center,the choroidal thickness(CHT)and choroidal vascular index(CVI)of the macular zone were examined by SS-OCTA,the image was divided into three ring areas according to the Early Treatment Diabetic Retinopathy Study(ETDRS):the subfoveal macular area(diameter of 0-1 mm),the inner ring area(diameter of 1-3 mm)and the outer ring area(diameter of 3-6 mm).The right eye data were analyzed.One-way ANOVA was used to compare CHT in the three ring areas and in the four regions(superior,temporal,inferior and nasal regions)of the inner and outer ring areas.Univariate linear regression and multiple linear regression analysis were used to analyze the correlation between the CHT of the three ring areas and gender,age,the spherical equivalent(SE),the SE of parents,axial length(AL),pupil diameter(PD)and CVI.Results:The mean CHT of the subfoveal macular area,inner ring area and outer ring area were 320±58μm,315±55μm and 299±47μm,respectively(F=2.77,P=0.065).The CHT of the outer ring area was thinner than that of the subfoveal macular area(t=2.20,P=0.025),and there were no signifcant differences between the other two ring areas(P>0.05).There were signifcant differences in CHT among the nine regions(the subfoveal macular area,the superior,temporal,inferior and nasal regions of the inner and outer ring areas)(F_(different regions)=19.20,P<0.001).Both in the inner ring area and the outer ring area,there were signifcant differences in CHT of the four regions of each ring area(F_(Inner ring area)=8.15,P<0.001;F_(Outer ring area)=43.11,P<0.001),among

关 键 词：脉络膜 正视儿童 扫频源光学相干断层扫描血管成像 相关因素 

分 类 号：R779.7[医药卫生—眼科]