烟酸及其衍生物:从传统营养素到肿瘤防治的新认识  

Renewed understanding of nicotinic acid and its derivatives:from traditional nutrients to cancer prevention and treatment

作　　者：李昊 安家兴 王倩 LI Hao;AN Jiaxing;WANG Qian(Oral Disease Research Key Laboratory of Guizhou Tertiary Institution,School of Stomatology,Zunyi Medical University,Zunyi 563000,Guizhou,China;Microbial Resources and Drug Development Key Laboratory of Guizhou Tertiary Institution,Zunyi Medical University,Zunyi 563000,Guizhou,China)

机构地区：[1]遵义医科大学口腔医学院贵州省普通高等学校口腔疾病研究特色重点实验室,贵州遵义563000 [2]遵义医科大学贵州省普通高等学校微生物资源与药物开发特色重点实验室,贵州遵义563000

出　　处：《中国肿瘤生物治疗杂志》2023年第2期108-113,共6页Chinese Journal of Cancer Biotherapy

基　　金：国家自然科学基金资助项目(No.82160112);遵义医科大学优秀青年人才项目(No.17zy-002)。

摘　　要：烟酸属于B族维生素,是人体必需的维生素之一。过去对烟酸功能的认知主要停留在营养素层面,如参与维持神经功能、促进代谢和发育、保护心脑血管等。随着研究的不断深入,近年来已有多项研究表明,烟酸及其衍生物能起到预防和辅助治疗癌症的作用。烟酸及其衍生物不仅影响肿瘤细胞的生物学功能、参与免疫调节,还能对烟酰胺磷酸核糖转移酶(NAMPT)抑制剂的抗肿瘤疗效起到辅助作用,并以多聚ADP-核糖聚合酶(PARP)依赖方式通过多种分子途径维持基因组的稳定性。本文总结了烟酸及其衍生物在肿瘤中作用的研究脉络和最新进展,并展望其进一步研究和应用方向,对烟酸及其衍生物在肿瘤综合防治中的应用有一定的指导作用。Nicotinic acid belongs to B vitamins and is one of the essential vitamins for humans.In the past,the main cognition of nicotinic acid remained on its nutritional functions,such as participating in the maintenance of neural function,the promotion of metabolism and development,and the protection of cardio cerebral vessels.With the development of researches,in recent years,multiple studies have shown that nicotinic acid and its derivatives play key roles in the prevention and treatment of cancer.Nicotinic acid and its derivatives could affect the biological functions of tumor cells,participate in immune regulation,promote the antitumor efficacy of nicotinamide phosphoribosyltransferase(NAMPT)inhibitors,and maintain the genomic stability through a variety of molecular pathways in a poly ADP-ribose polymerase(PARP)-dependent manner.This review summarizes the research approaches and the latest progress in the studies of the role nicotinic acid and its derivatives play in cancer prevention and treatment and assess the prospects of its further research and application direction,with the hope of helping promote the application of nicotinic acid and its derivatives in comprehensive cancer prevention and treatment.

关 键 词：烟酸 烟酰胺 肿瘤 烟酰胺腺嘌呤二核苷酸 烟酰胺磷酸核糖转移酶 免疫 基因组稳定性 

分 类 号：R730.1[医药卫生—肿瘤] R730.5[医药卫生—临床医学]