辅助分析软件拼图核型分析法在染色体识别教学中的作用探讨  

The role of jigsaw karyotype analysis in the teaching of chromosomal recognition

作　　者：郑杰梅[1] 赖怡[1] Zheng Jiemei;Lai Yi(Department of Medical Genetics/Prenatal Diagnosis Center,West China Second University Hospital,Sichuan University,Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University)of the Ministry of Education,Chengdu,Sichuan 610041,China)

机构地区：[1]四川大学华西第二医院医学遗传科/产前诊断中心,四川大学出生缺陷与相关妇儿疾病教育部重点实验室,成都610041

出　　处：《中华医学遗传学杂志》2023年第3期374-377,共4页Chinese Journal of Medical Genetics

摘　　要：染色体核型分析是遗传学最基础的检测方法,也是诊断染色体病的"金标准"。传统的核型分析需要人工对染色体进行识别。能够熟练识别染色体的教学培训时间较长、内容枯燥,且每个学员对染色体形态的掌握能力差异较大,因此需要对传统的核型分析教学过程进行改进。四川大学华西第二医院产前诊断中心在传统教学的基础上,增加了辅助分析软件拼图核型分析教学。此方法不仅提升了学员对于核型分析实践操作中兴趣和能力,使其能够在短时间内牢记正常染色体的特征区带,并且通过对大量核型图像的学习,增强了对染色体异常的识别能力。Karyotype analysis is the basic method in cytogenetics,and is also recognized as the"gold standard"for diagnosing chromosomal disorders.The teaching and training for traditional karyotyping analysis is time-consuming and even boring.The individual′s ability for mastering the chromosome morphology can vary greatly.Therefore,it is necessary to improve the teaching method.On the basis of the traditional method,we have added auxiliary analysis software during the teaching.This type of splicing karyotype teaching has increased the students′interest and improved their ability for karyotyping,allowing them to quickly remember the characteristic bands of chromosomes.Through enhanced memory of a large number of karyotypic images,the students′ability to recognize individual chromosomes has improved.

关 键 词：染色体识别 核型分析 剪切 拼接 

分 类 号：G642[文化科学—高等教育学] R-4[文化科学—教育学]