胶质细胞在阿尔茨海默病中作用机制的研究进展  

Advances in the mechanism of glial cells in Alzheimer's disease

作　　者：王悦 邓希锦[2] Wang Yue;Deng Xijin(Basic Medical Department,Harbin Vocational&Technical College,Harbin 150076,China;Anesthesia Department,the Second Affliated Hospital of Harbin Medical University,Harbin 150086,China)

机构地区：[1]哈尔滨职业技术学院医学院基础医学教研室,哈尔滨150076 [2]哈尔滨医科大学附属二院麻醉科,哈尔滨150086

出　　处：《国际免疫学杂志》2022年第6期646-650,共5页International Journal of Immunology

摘　　要：阿尔茨海默病(Alzheimer's disease,AD)是一种较为常见的神经退行性疾病。AD的具体发病机制尚不清楚,可能与胶质细胞的增生分化相关。哺乳动物的神经系统主要由神经元和胶质细胞组成。胶质细胞不产生电信号,被认为是神经元的支持细胞。胶质细胞可分化为小胶质细胞、星形胶质细胞和少突胶质细胞。三者在AD的发生发展过程中发挥着不同的作用。Alzheimer's disease(AD)is a common neurodegenerative disease.The pathogenesis is still unclear,which may be related to the proliferation and differentiation of glial cells.Mammalian nervous system is mainly composed of neurons and glial cells.Glial cells do not produce electrical signals and are considered to be the supporting cells of neurons.Glial cells can be differentiated into microglia,astrocytes and oligodendrocytes.They play different roles in the occurrence and development of AD.

关 键 词：胶质细胞 阿尔茨海默病 神经退行性疾病 

分 类 号：R749.16[医药卫生—神经病学与精神病学]