圆锥角膜发病机制研究进展  

Research Progress in Pathogenesis of Keratoconus

作　　者：吴蕾 金奇芳[1] WU Lei;JIN Qi-fang(Department of Ophthalmology,the Second Affiliated Hospital of Nanchang University,Nanchang 330038,China)

机构地区：[1]南昌大学第二附属医院眼科,南昌330038

出　　处：《实用临床医学（江西）》2023年第1期135-138,共4页Practical Clinical Medicine

摘　　要：圆锥角膜是以角膜中央或旁中央扩张变薄并向前呈锥形突出为特征的原发性角膜变性,常造成不可逆的不规则散光和不同程度矫正视力下降。其发病机制尚不明确,是一种和多种因素相关的复杂疾病,缺乏早期诊断和有效的治疗手段。文章就近年对圆锥角膜的相关发病机制进行综述,其中重点阐述炎症因子及激素的作用,以期为圆锥角膜的诊疗提供新方向。Keratoconus is a primary corneal degeneration characterized by central or paracentric dilatation and conical protruding forward,often resulting in irreversible irregular astigmatism and varying degrees of impairment of corrected vision.As a complex disease related to multiple factors,keratoconus lacks early diagnosis and effective treatment due to its pathogenesis is not clear.This article reviews the pathogenesis of keratoconus with emphasis on the role of inflammatory factors and hormones,in order to provide a new direction for the diagnosis and treatment of keratoconus.

关 键 词：圆锥角膜 发病机制 炎症因子 激素 

分 类 号：R774[医药卫生—眼科]