Targeted nanomedicines remodeling immunosuppressive tumor microenvironment for enhanced cancer immunotherapy  

作　　者：Yanyan Xu Jingyuan Xiong Xiyang Sun Huile Gao 

机构地区：[1]Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry,Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology,West China School of Pharmacy,Sichuan University,Chengdu 610041,China [2]Healthy Food Evaluation Research Center,West China School of Public Health and West China Fourth Hospital,Sichuan University,Chengdu 610041,China [3]Hongqiao International Institute of Medicine,Tongren Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200336,China

出　　处：《Acta Pharmaceutica Sinica B》2022年第12期4327-4347,共21页药学学报（英文版）

基　　金：This study was supported by National Natural Science Foundation of China(82173762);111 Project(B18035,China);the Key Research and Development Program of Science and Technology Department of Sichuan Province(2022JDJQ0050,2022YFS0334).

摘　　要：Cancer immunotherapy has significantly flourished and revolutionized the limited conventional tumor therapies,on account of its good safety and long-term memory ability.Discouragingly,low patient response rates and potential immune-related side effects make it rather challenging to literally bring immunotherapy from bench to bedside.However,it has become evident that,although the immunosuppressive tumor microenvironment(TME)plays a pivotal role in facilitating tumor progression and metastasis,it also provides various potential targets for remodeling the immunosuppressive TME,which can consequently bolster the effectiveness of antitumor response and tumor suppression.Additionally,the particular characteristics of TME,in turn,can be exploited as avenues for designing diverse precise targeting nanomedicines.In general,it is of urgent necessity to deliver nanomedicines for remodeling the immunosuppressive TME,thus improving the therapeutic outcomes and clinical translation prospects of immunotherapy.Herein,we will illustrate several formation mechanisms of immunosuppressive TME.More importantly,a variety of strategies concerning remodeling immunosuppressive TME and strengthening patients'immune systems,will be reviewed.Ultimately,we will discuss the existing obstacles and future perspectives in the development of antitumor immunotherapy.Hopefully,the thriving bloom of immunotherapy will bring vibrancy to further exploration of comprehensive cancer treatment.

关 键 词：Cancer immunotherapy Immunosuppressive tumor microenvironment Tumor microenvironment normalization Targeted nanomedicines Drug delivery Environment-responsive nanoparticles Combinational therapy Tumor treatment 

分 类 号：R730.51[医药卫生—肿瘤]