痛泻要方物质基础及药理作用研究进展  

Material Basis and Pharmacological Action of Tongxie Yaofang:A Review

作　　者：赵清玉 张淼[1] 赵文静[1] 王一鸣 隋方宇[1] 关子赫 旺建伟[1] ZHAO Qingyu;ZHANG Miao;ZHAO Wenjing;WANG Yiming;SUI Fangyu;GUAN Zihe;WANG Jianwei(School of Basic Medical Sciences,Heilongjiang University of Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学基础医学院,哈尔滨150040

出　　处：《中国实验方剂学杂志》2023年第8期237-245,共9页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金面上项目(81573870);中国博士后科学基金第八批特别资助项目(2015T80376);黑龙江省自然科学基金面上项目(H2015020);黑龙江中医药大学优秀青年骨干教师支持计划项目(15041190044);全国中医药创新骨干人才培养项目(国中医药人教函[2019]128号);黑龙江省中医药文化项目(ZYW2022-127)。

摘　　要：痛泻要方,也称白术芍药散,最早出自元代朱丹溪的《丹溪心法》,由白术、白芍、陈皮、防风4味中药组成,是治疗痛泻的代表方剂。有补脾柔肝、缓痛止泻之功,临床主要用于肠易激综合征(IBS)、溃疡性结肠炎(UC)等消化道疾病的治疗,另对小儿顽固性厌食症、郁证、呼吸道疾病等有良好的作用,特别在消化道疾病伴随精神心理异常上有独特疗效。实验研究和临床实践均表明,痛泻要方治疗疾病有多成分、多途径、多靶点的特点。痛泻要方治疗疾病的作用机制主要集中于抗炎、调节免疫功能、改善肠道高敏性、调节情志等,其含有的单萜糖苷类、黄酮类、色原酮类、内酯类等成分发挥了重要的治疗作用。痛泻要方代谢组学、蛋白组学、网络药理学等系统生物学的研究为阐明其作用机制,扩大临床应用范围提供了科学依据。但目前仍存在病证难以结合、系统研究不深入等问题有待解决,该文通过相关文献的检索与整理,系统梳理了痛泻要方的物质基础、药理作用及系统生物学研究,以期为深入研究其治疗疾病的作用机制以更好地用于临床实践奠定基础。Tongxie Yaofang,also known as Baizhu Shaoyaosan,was first recorded in Danxi's Experiential Therapy(《丹溪心法》)by ZHU Danxi in the Yuan dynasty.It is composed of Atractylodis Macrocephalae Rhizoma,Paeoniae Radix Alba,Citri Reticulatae Pericarpium,and Saposhnikoviae Radix,and serves as the representative prescription for the treatment of painful diarrhea.It has the functions of tonifying the spleen,emolliating the liver,relieving pain,and checking diarrhea,and is mainly used in the treatment of gastrointestinal diseases such as irritable bowel syndrome(IBS)and ulcerative colitis(UC).In addition,it is effective in treating gastrointestinal disorders with mental and psychological abnormalities,as well as obstinate anorexia in children,depression syndrome,and respiratory diseases.Experimental research and clinical practice have shown that Tongxie Yaofang has multi-component,multi-pathway,and multi-target characteristics in the treatment of diseases.The mechanism of Tongxie Yaofang in treating diseases is mainly attributed to anti-inflammation,immune function regulation,intestinal hypersensitivity improvement,emotion regulation,etc.

关 键 词：痛泻要方 物质基础 药理作用 系统生物学 肠道疾病 

分 类 号：R2-0[医药卫生—中医学] R22R285.5R284R33