德宏州少数民族女性宫颈人乳头瘤病毒基因分型与宫颈病变的相关性研究  

Correlation between cervical human papillomavirus genotyping and cervical lesions among ethnic minorities in Dehong Prefecture

作　　者：罗祥美 杨玉崟 彭泱泱 刘宝兰 尹锦芳 杨庆东 唐玲 王璐[1] 许湘盈 李姚 LUO Xiang-mei;YANG Yu-yin;PENG Yang-yang;LIU Bao-lan;YIN Jin-fang;YANG Qing-dong;TANG Ling;WANG Lu;XU Xiang-ying;LI Yao(Department of Gynecology,Dehong Hospital,Kunming Medical University,Kunming,Yunnan 678400,China)

机构地区：[1]昆明医科大学附属德宏医院妇科,云南昆明678400

出　　处：《中国妇幼保健》2023年第6期1084-1088,共5页Maternal and Child Health Care of China

基　　金：云南省科技计划项目(202001AY070001-171)。

摘　　要：目的 分析德宏州少数民族女性宫颈人乳头瘤病毒(HPV)基因分型与宫颈病变的相关性,明确少数民族女性宫颈HPV与宫颈病变的临床意义,为德宏州制定相应宫颈癌预防策略奠定基础。方法 随机抽取2017年9月—2021年9月在昆明医科大学附属德宏医院就诊的汉族、傣族、景颇族及其他少数民族(包括阿昌族、德昂族及傈僳族)感染宫颈HPV的患者2 256例,分析宫颈HPV与宫颈病变是否存在相关性。结果 1 374例(71.4%)汉族患者发生宫颈病变,207例(84.8%)傣族患者发生宫颈病变,46例(85.2%)景颇族患者发生宫颈病变,23例(69.7%)其他少数民族(包括阿昌族、德昂族及傈僳族)患者发生宫颈病变,差异有统计学意义(χ^(2)=24.224,P<0.05)。在同种类型HPV感染情况下,民族与宫颈病变存在弱相关(P<0.05)。结论 在感染HPV的情况下,民族与宫颈病变是相关的,但其相关性较弱;在确定民族的情况下,HPV感染类型与宫颈病变是相关的;在HPV感染类型相同的情况下,感染HPV51、HPV68的患者中傣族较其他民族易发生宫颈病变;感染HPV16、HPV58的患者中,少数民族较汉族易发生宫颈病变。Objective To analyze the correlation between ethnic minority cervical HPV genotyping and cervical lesions in Dehong Prefecture, clarify the clinical significance of ethnic minority cervical HPV and cervical lesions, lay a foundation for the formulation of corresponding cervical cancer prevention strategies in Dehong Prefecture.Methods A total of 2 256 patients from Han, Dai, Jingpo, and other ethnic minorities(including Achang, Deang, and Lisu nationalities) treated in Dehong Hospital, Kunming Medical University from September 2017 to September 2021 were randomly selected to analyze whether there was a correlation between ethnic minority cervical HPV genotyping and cervical lesions.Results Cervical lesions occurred in 1 374 Han patients(71.4%), 207 Dai patients(84.8%), 46 Jingpo patients(85.2%), and 23 patients(69.7%) of other ethnic minorities(including Achang, Deang, and Lisu nationalities), respectively, there was statistically significant difference(χ^(2)=24.224, P<0.05).In the case of HPV infection of the same type, nationality and cervical lesions were weakly related(P<0.05).Conclusion In the case of HPV infection, nationality and cervical lesions are related, but the correlation is weak;in the case of HPV infection of the same type, Dai patients with HPV51 and HPV68 infection are more prone to cervical lesions compared with the other ethnic groups;among the patients with HPV16 and HPV58 infection, ethnic minorities are prone to cervical lesions compared with Han patients.

关 键 词：人乳头瘤病毒 少数民族 宫颈病变 

分 类 号：R737.33[医药卫生—肿瘤]