过敏原组分检测在IgE介导的食物过敏中的研究进展  

The advances of allergen component detection in IgE-mediated food allergy

作　　者：陈浩[1] 祝戎飞 廖晓棠 孙宝清 Chen Hao;Zhu Rongfei;Liao Xiaotang;Sun Baoqing(Department of Allergy,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;Hunan Center for Drug Evaluation and Adverse Reaction Monitoring,Changsha 410013,China;State Key Laboratory of Respiratory Disease,National Clinical Research Center for Respiratory Disease,Guangzhou Institute of Respiratory Health,First Affiliated Hospital of Guangzhou Medical University,Guangzhou 510120,China)

机构地区：[1]华中科技大学同济医学院附属同济医院过敏反应科,武汉430030 [2]湖南省药品审评与不良反应监测中心,长沙410013 [3]呼吸疾病国家重点实验室,呼吸疾病国家临床医学研究中心,广州呼吸健康研究院,广州医科大学附属第一医院变态反应科,广州510120

出　　处：《中华预防医学杂志》2023年第3期333-340,426,共9页Chinese Journal of Preventive Medicine

基　　金：广东省钟南山医学基金会资助项目(ZNSXS-20220042)。

摘　　要：食物过敏在全球的患病率不断上升,而IgE介导的食物过敏是最常见的临床类型。目前食物过敏检查方式主要依赖于针对提取物的皮肤点刺试验以及血清特异性IgE检测,但这种检测方式无法鉴别不同过敏原之间的交叉致敏。食物过敏原组分检测能够识别食物的主要过敏原组分以及交叉组分,在常见食物过敏患者中的饮食指导、预后监测以及特殊类型的食物过敏的诊断中具有重要价值。本文列举了IgE介导的常见食物过敏,如牛奶与鸡蛋过敏、海鲜过敏以及特殊类型的食物过敏,如猫猪肉综合征、口腔过敏综合征、α-半乳糖综合征、食物依赖运动诱发的严重过敏反应的特点,阐述了过敏原组分检测在这些类型的IgE介导的食物过敏中的进展,以期为IgE介导的食物过敏的诊断、治疗与预防提供依据。There are many types in food allergy,and the most common is mediated by IgE.Currently,the diagnosis of food allergy mainly relied on skin prick test and serum specific IgE of allergen extract,which can not identify cross-sensitization.Component-resolved diagnosis(CRD)can identify the major allergen components and cross-components of food allergens,which plays an important role in dietary guidance,prognosis monitoring and diagnosis of special types of IgE-mediated food allergy.This article enumerates clinical characteristics of the IgE-mediated common food allergies,such as milk,egg and seafood allergy,and special type of food allergy,such as cat pork syndrome,oral allergy syndrome,α-gal syndrome and food-dependent exercise-induced anaphylaxis,summarizes the advances of CRD in these types of IgE-mediated food allergy,in order to provide an evidence for the diagnosis,treatment and prevention of IgE-mediated food allergy.

关 键 词：过敏原 致敏 免疫球蛋白E 组分解析诊断 食物过敏 

分 类 号：R155.3[医药卫生—营养与食品卫生学]