pH响应型抗菌纳米材料在抑制口腔菌斑生物膜领域的研究进展  

Research progress in pH-responsive antibacterial nanomaterials for inhibiting oral plaque biofilms

作　　者：曲珊琳 于烁 马晓琳 王瑞[1] Shanlin Qu;Shuo Yu;Xiaolin Ma;Rui Wang(Department of Preventive Dentistry,Hospital of Stomatology,Jilin University,Changchun 130021,China)

机构地区：[1]吉林大学口腔医院口腔预防科,长春130021

出　　处：《中华口腔医学杂志》2023年第3期292-297,共6页Chinese Journal of Stomatology

基　　金：吉林省卫生健康科技能力提升项目(2021JC029);吉林省卫生健康研究项目(2021JK02)。

摘　　要：pH响应型抗菌纳米材料是一种可根据机体在生理和病理条件下产生的显著pH差异,选择性地发生结构变化并触发药物释放的新型纳米材料。菌斑内酸性微环境的形成是口腔菌斑生物膜具备致龋性的关键,这也为pH响应型抗菌纳米材料的口腔应用创造了条件。pH响应型抗菌纳米材料能够响应菌斑微环境酸碱度的变化,精准控制抗菌药物的释放,为提高药物效能以及靶向抗菌提供了新方向。本文从pH响应型抗菌纳米材料的分类、作用机制、在抑制口腔菌斑生物膜领域的应用方面进行综述。pH-responsive antibacterial nanomaterials are a new type of nanomaterials that can selectively undergo structural changes and trigger drug release according to significant pH differences produced by the body under physiological and pathological conditions.The formation of acidic microenvironment in plaque is the key to the pathogenicity of oral plaque biofilm,which also creates conditions for the oral application of pH-responsive antibacterial nanomaterials.pH-responsive antibacterial nanomaterials can respond to changes in pH of plaque microenvironment and accurately control the release of antibacterial drugs,providing a new direction for improving drug efficacy and targeted antibacterial.The present article reviews the classification,mechanism and application of pH-responsive antibacterial nanomaterials in oral plaque inhibition.

关 键 词：牙菌斑 生物膜 纳米粒子 抗菌药 生物医学和牙科材料 PH响应 

分 类 号：R783.1[医药卫生—口腔医学]