基因修饰兔的发展及其在人类疾病研究中的应用  

Development of genetically modified rabbits and their applications in human disease research

作　　者：陶源 刘忠华[1] 宋军[1] TAO Yuan;LIU Zhonghua;SONG Jun(College of Life Sciences,Northeast Agricultural University,Harbin 150030,China)

机构地区：[1]东北农业大学生命科学学院,哈尔滨150030

出　　处：《中国比较医学杂志》2023年第3期98-109,142,共13页Chinese Journal of Comparative Medicine

基　　金：国家自然科学基金(32070540)。

摘　　要：兔是生物医学研究中的经典动物模型,由于缺乏多能干细胞(pluripotent stem cells,PSCs)和兔体细胞核移植(somatic cell nuclear transfer,SCNT)技术的低效,使得兔模型的发展受到阻滞。近年来随着ZFNs、TALENs和CRISPR/Cas9等基因编辑技术的出现,基因修饰兔的研究取得快速发展,其在生物、医学领域所扮演的角色也越来越重要。本文归纳了兔与人类疾病模型的发展历程以及在相关疾病领域的研究,并对未来动物模型应具备的特点进行展望,旨在推动人类疾病模型兔的发展。The rabbit is a classical animal model in biomedical research.The development of genetically modified rabbit models has been severely impeded because of the lack of pluripotent stem cells and the extremely low efficiency of somatic cell nuclear transfer.With the rapid development of novel genome-editing techniques,such as ZFNs,TALENs,and CRISPR/Cas9,genetic engineering of rabbits has developed rapidly.Genetically modified rabbit models are playing increasingly important roles in the field of biomedicine.In this review,we discuss the development of genetically modified rabbit models and their applications in human disease research to provide a theoretical reference for promoting the development of human disease animal models.

关 键 词：兔 人类疾病 基因修饰 动物模型 

分 类 号：R-33[医药卫生]