Extension of the Lifespan of a Mouse Model of Rett Syndrome by Intracerebroventricular Delivery of MECP2  

作　　者：Kan Yang Cheng Cheng Yiting Yuan Yuefang Zhang Shifang Shan Zilong Qiu 

机构地区：[1]Center for Excellence in Brain Science and Intelligence Technology,Institute of Neuroscience,State Key Laboratory of Neuroscience,CAS Key Laboratory of Primate Neurobiology,Chinese Academy of Sciences,Shanghai 200031,China [2]Belief BioMed(Shanghai),Co.,Ltd.,Shanghai 200032,China [3]National Clinical Research Center for Aging and Medicine,Huashan Hospital,Fudan University,Shanghai 200040,China

出　　处：《Neuroscience Bulletin》2023年第2期297-302,共6页神经科学通报（英文版）

基　　金：supported by grants from the Youth Innovation Promotion Association Chinese Academy of Sciences(2022269);the Youth Science Fund of State Key Laboratory of Neuroscience(SKLN-2022B006);the National Natural Science Foundation of China(82001211,81941015,82021001);the CPSF-CAS Joint Foundation for Excellent Postdoctoral Fellows(2017LH036);the China Postdoctoral Science Foundation(2017M620173);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDBS01060200);the Program of Shanghai Academic Research Leader,the Open Large Infrastructure Research of Chinese Academy of Sciences,the Shanghai Municipal Science and Technology Major Project(2018SHZDZX05);the Guangdong Key Scientific and Technological Project(2018B030335001).

摘　　要：DearEditors,Rett Syndrome(RTT)is a severe neurodevelopmental disorder characterized by neural dysfunctions and a reduced lifespan,mainly in female patients,involving loss-of-function mutations in the methyl-CpG binding protein 2(MECP2)gene[1-4].

关 键 词：MECP2 EXTENSION NEURAL 

分 类 号：R338[医药卫生—人体生理学]