The epidermal immune microenvironment plays a dominant role in psoriasis development,as revealed by mass cytometry  

作　　者：Yuan Zhou Fan Xu Xue-Yan Chen Bing-Xi Yan Zhao-Yuan Wang Si-Qi Chen Min Zheng Xiao-Yong Man 

机构地区：[1]Department of Dermatology,Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,China

出　　处：《Cellular & Molecular Immunology》2022年第12期1400-1413,共14页中国免疫学杂志（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China (Nos.81930089,82103709,and 82230104).

摘　　要：Psoriasis is a common chronic inflammatory skin disease.The diversity and heterogeneity of immune cells in human skin have been studied in recent years,but the spatial distribution of immune cells at the single-cell level in the human psoriatic epidermis and dermis remains unclear.In this study,we mapped psoriatic skin immune cells from paired lesional,perilesional,and nonlesional skin samples using mass cytometry.Phenotypic dendritic cells(DCs)were found in the psoriatic epidermis and dermis.Psoriatic dermal CD1c^(+)CD11b^(+)cDC2s migrated to the epidermis in the perilesional skin during the preinitiation stage.CD1c^(+)CD11b^(+)cDC2s rapidly replaced EpCAM^(+)CD11c^(low) LC cells and initiated inflammation.Simultaneously,CD207^(+)CD11c^(hi) LC and CD5^(+)T cells accumulated in the psoriatic epidermis and orchestrated epidermal inflammation in psoriasis.The immune cell pool in the psoriatic dermis primarily included APCs and T cells.However,unlike that in the dermis,the epidermal immune environment was more significant and coincided with the inflammation occurring during psoriasis.

关 键 词：PSORIASIS Cutaneous immune Mass cytometry Dendritic cell 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]