胃癌根治术后腹腔引流液癌胚抗原水平的临床意义  

Clinical significance of carcinoembryonic antigen level in abdominal drainage fluid after radical gastrectomy

作　　者：黄少雄[1] 邱仙土[1] 刘惠滨[1] 陈俊伟 林伟[1] HUANG Shaoxiong;QIU Xiantu;LIU Huibin;CHEN Junwei;LIN Wei(Department of Gastrointestinal Surgery,Affiliated Hospital of Putian University,Putian 351100,China)

机构地区：[1]莆田学院附属医院胃肠外科,福建莆田351100

出　　处：《汕头大学医学院学报》2023年第1期29-33,共5页Journal of Shantou University Medical College

基　　金：福建省中青年教师教育研究项目(JAT220286)。

摘　　要：目的:探讨胃癌根治术后第1天腹腔引流液中癌胚抗原(carcinoembryonic antigen,CEA)水平在胃癌患者预后中的临床意义。方法:选取2018年8月—2019年6月在莆田学院附属医院接受胃癌根治术的93例患者作为研究对象,其中男性63例,女性30例,中位数年龄65岁(范围35~83岁)。根据患者术后第1天腹腔引流液中CEA的表达水平分为CEA阳性组(CEA≥5 ng/mL)和CEA阴性组(CEA<5 ng/mL)。采用Logistic回归分析胃癌术后第1天腹腔引流液CEA表达水平的影响因素,采用Kaplan-Meier法和Cox回归分析腹腔引流液CEA水平与预后的关系。结果:多因素Logistic回归分析显示,体重指数(OR=0.205,P=0.029)和pTNM分期(OR=3.477,P=0.015)是影响腹腔引流液CEA水平的独立因素。Cox回归分析显示,pTNM分期(HR=13.047,P<0.001)和组织学分化程度(HR=5.663,P=0.017)是影响胃癌患者预后的独立因素。结论:胃癌患者术后第1天腹腔引流液的CEA水平具有作为预后指标的潜力。Objective:To investigate the clinical significance of carcinoembryonic antigen(CEA)level in the abdominal drainage fluid on the first day after radical gastrectomy for the prognosis of patients with gastric cancer.Methods:Ninety-three patients who underwent radical gastrectomy for gastric cancer at the Affiliated Hospital of Putian College from August 2018 to June 2019 were selected as study subjects,including 63 males and 30 females with a median age of 65 years(range 35-83 years old).The patients were divided into CEA-positive group(CEA≥5 ng/mL)and CEA-negative group(CEA˂5 ng/mL)according to the expression level of CEA in the abdominal drainage fluid on the 1st postoperative day.Logistic regression was used to analyze the factors influencing the CEA expression level in the abdominal drainage fluid on the first day after gastric cancer surgery,and Kaplan-Meier method and Cox regression were used to analyze the relationship between the CEA level in the abdominal drainage fluid and prognosis.Results:Multifactorial logistic regression analysis showed that body mass index(OR=0.205,P=0.029)and pTNM stage(OR=3.477,P=0.015)were independent factors affecting the level of CEA in abdominal drainage fluid.Cox regression analysis showed that pTNM stage(HR=13.047,P<0.001)and the degree of histological differentiation(HR=5.663,P=0.017)were independent factors influencing the prognosis of patients with gastric cancer.Conclusion:The level of CEA in abdominal drainage fluid of patients with gastric cancer on the first day after operation has the potential to be used as a prognostic indicator.

关 键 词：胃肿瘤 癌胚抗原 胃癌根治术 预后 

分 类 号：R735.2[医药卫生—肿瘤]