清开灵注射液辅助常规西医治疗缺血性脑卒中患者的临床疗效及对血清炎症免疫介质表达的影响  

Clinical Effect of Qingkai Ling Injection Assisted Conventional Western Medicine on Treatment of Ischemic Stroke and Its Influence on Serum Inflammatory Immune Mediator Expression

作　　者：潘静 杨丽平 张娟 PAN Jing;YANG Li-ping;ZHANG Juan(General Medical Department,First Affiliated Hospital of Air Force Military Medical University,Xi′an Shanxi 710032)

机构地区：[1]空军军医大学第一附属医院综合诊疗科,陕西西安710032

出　　处：《世界中西医结合杂志》2023年第2期309-313,共5页World Journal of Integrated Traditional and Western Medicine

基　　金：陕西省中医管理局中医药科研课题(19-LC159)。

摘　　要：目的观察清开灵注射液辅助常规西医治疗缺血性脑卒中(Ischemic stroke,IS)患者的临床疗效及对血清炎症免疫介质表达的影响。方法选取2019年1月—2020年11月期间空军军医大学第一附属医院收治的88例IS患者作为研究对象,采用随机数字表法将其分为对照组与治疗组,每组各44例。对照组给予常规西医治疗,治疗组在常规西医基础上联合清开灵注射液治疗。治疗2周后,观察比较两组患者临床疗效、中医证候疗效、治疗安全性、治疗前后神经功能评分(National Institutes of Health Stroke Scale,NIHSS)及血清免疫炎症因子[白细胞介素-1β(Interleukin-1β,IL-1β)、白细胞介素-2(Interleukin-2,IL-2)、肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)]水平变化。结果治疗后治疗组临床总有效率95.45%(42/44)较对照组81.82%(36/44)明显升高,差异有统计学意义(P<0.05)。治疗后治疗组中医证候总有效率90.91%(40/44)较对照组70.45%(31/44)明显升高,差异有统计学意义(P<0.05)。治疗后两组患者NIHSS评分均较治疗前降低,差异有统计学意义(P<0.05);且治疗组较对照组明显降低,差异有统计学意义(P<0.05)。治疗后两组患者血清IL-1β、IL-2、TNF-α水平均较治疗前降低,差异有统计学意义(P<0.05);且治疗组较对照组明显降低,差异有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论清开灵注射液辅助常规西医治疗IS安全、有效,有利于减轻患者神经功能缺损程度,且可能与下调血清炎症免疫介质表达有关。Objective To explore the clinical effect of Qingkai Ling Injection assisted conventional western medicine on the treatment of ischemic stroke(IS)and its influence on serum inflammatory immune mediator expression.Methods Eighty-eight patients with IS who were admitted to the First Affiliated Hospital of Air Force Military Medical University from January 2019 to November 2020 were divided into a control group and a treatment group using the random number table method,with 44 cases in each group.The control group was given conventional western medical treatment,and the treatment group was treated with Qingkai Ling Injection combined with conventional western medicine.After 2 weeks of treatment,the clinical effect,traditional Chinese medicine(TCM)syndrome efficacy,therapeutic safety,National Institutes of Health Stroke Scale(NIHSS)scores,and serum levels of immune-inflammatory factors[interleukin-1β(IL-1β),interleukin-2(IL-2),and tumor necrosis factor-α(TNF-α)]before and after treatment were compared between the two groups.Results After treatment,the total clinical effective rate of the treatment group was 95.45%(42/44),which was higher than that of the control group[81.82%(36/44)](P<0.05).After treatment,the total effective rate of TCM syndromes in the treatment group was 90.91%(40/44),which was higher than that in the control group[70.45%(31/44)](P<0.05).The NIHSS scores of both groups decreased after treatment,and the score of the treatment group was lower than that of the control group(P<0.05).After treatment,the levels of IL-1β,IL-2,and TNF-αin the two groups were lower than those before treatment(P<0.05),and the treatment group was lower than the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Qingkai Ling Injection assisted conventional western medicine is safe and effective in the treatment of IS,which helps alleviate the degree of neurological deficits in patients and may be associated with the down-regulation of

关 键 词：缺血性脑卒中 清开灵注射液 神经功能 中医证候 炎症免疫介质 

分 类 号：R743.3[医药卫生—神经病学与精神病学]