环状RNA与环境相关疾病  

Circular RNA and environmental related diseases

作　　者：李美珍 蒋义国[1] LI Meizhen;JIANG Yiguo(Institute for Chemical Carcinogenesis of Guangzhou Medical University,State Key Laboratory of Respiratory Disease,Guangzhou 511436,China)

机构地区：[1]广州医科大学化学致癌研究所,呼吸疾病国家重点实验室,广州511436

出　　处：《广州医药》2023年第3期1-7,共7页Guangzhou Medical Journal

基　　金：国家自然科学基金重点项目(82130095),国家自然科学基金重大研究计划重点支持项目(91643204)。

摘　　要：人类疾病的发生发展是环境因素与遗传学因素相互作用的结果。环境有害暴露导致的机体功能紊乱和疾病发生,与细胞内环状RNA(circRNA)的表达异常有密切关系,circRNA的功能和作用是医学研究的热点领域。circRNA是表观遗传学的一类具有环状结构的RNA分子,由于其特殊的结构和复杂的功能,在调控疾病发生和病理过程中承担着重要角色。本文系统地介绍了circRNA的来源、功能,结合作者课题组的研究成就,综述了circRNA在环境有害暴露相关疾病中的作用和机制,探讨了circRNA作为潜在生物标志物在研究中所面临的挑战。The development of human diseases is the result of the interaction between environmental and genetic factor.Abnormal expression of cellular circular RNA(circRNA)is closely related to function disorders and diseases caused by environmental exposure.The function of circRNA is a research focus in medical science.CircRNA is the epigenetic molecular with circular structure.Because of its special structure and complex function,it plays an important role in the regulation of disease occurrence and pathological process.In this paper,the origin and functions of circRNA are systematically described.Combined with the achievements of the author s research group,the functions and mechanism of environmental exposure related diseases were reviewed.And the challenges of circRNA as a potential biomarker in research were discussed.

关 键 词：circRNA 表观遗传学 环境化学物 生物标志物 

分 类 号：R363[医药卫生—病理学]