肺癌患者术后放疗相关肺毒性的影响因素研究  

Research on the influence factors of postoperative radiotherapy related toxicity in patients with lung cancer

作　　者：卢衍毅 LU Yanyi(Dingtao District People’s Hospital of Heze,Heze 274199,Shandong)

机构地区：[1]定陶区人民医院,山东菏泽274199

出　　处：《菏泽医学专科学校学报》2023年第1期25-28,共4页Journal of Heze Medical College

摘　　要：目的探讨肺癌患者术后放疗发生放疗相关肺毒性(RILT)的影响因素。方法选择我院肺癌术后经放射治疗的患者86例,其中发生RILT患者25例,设置为观察组,未发生RILT患者61例设置为对照组,采用Logistic回归分析肺癌术后RILT产生的危险因素。结果观察组患者年龄>60岁、伴有肺部慢性疾病占比高于对照组(P<0.05);观察组放疗剂量>50 Gy、照射剂量5 Gy的肺组织占全肺总体积的百分比(V5)>45%、照射剂量20 Gy的肺组织占全肺总体积的百分比(V20)>23%、平均肺剂量(MLD)>10 Gy、同期化疗占比高于对照组(P<0.05)。结论年龄>60岁、合并肺部慢性疾病、放疗剂量>50 Gy、V5>45%、V20>23%、MLD>10 Gy、同期化疗为肺癌术后放疗发生RILT的独立危险因素。Objective To explore the influence factors of postoperative radiotherapy related toxicity in patients with lung cancer.Methods This research collated and analyzed the data of 86 patients with lung cancer who received postoperative radiotherapy in the hospital.Twenty-five patients with radiation-induced lung toxicity(RILT)were included in the observation group,and sixty-one patients without RILT were included in the control group.Risk factors influencing the occurrence of RILT were analyzed by logistic regression.Results The percentages of patients aged over 60 years or with chronic pulmonary diseases in the observation group were significantly higher than those of in the control group(P<0.05).The percentage of lung tissue with radiotherapy dose>50Gy and irradiation dose>5Gy in total lung volume(V5)>45%,the percentage of lung tissue with irradiation dose of 20Gy in total lung volume(V20)>23%,mean lung dose(MLD)>10Gy and concurrent chemotherapy in the observation group were significantly higher than those of the control group.Conclusion Age over 60 years,chronic pulmonary diseases,overall radiation dose>50Gy,V5>45%,V20>23%,MLD>10Gy and concurrent chemotherapy are independent risk factors for the occurrence of RILT.

关 键 词：肺癌 放疗相关肺毒性 危险因素 

分 类 号：R734.2[医药卫生—肿瘤]