氯桥联四核Bi(Ⅲ)配合物的合成和晶体结构及其抗癌活性  

Synthesis and Crystal Structure of a Tetranuclear Chlorido-Bridged Bi(Ⅲ)Complex and its Anticancer Activity

作　　者：盖爽爽 蒋才云[1] Gai Shuangshuang;Jiang Caiyun((Key Laboratory for Research and Development of Characteristic Yao,School of Food and Biochemical Engineering,Guangxi Science&Technology Normal University,Laibin 545004,China)

机构地区：[1]广西科技师范学院、食品与生化工程学院、特色瑶药资源研究与开发校级重点实验室,广西来宾545004

出　　处：《山东化工》2023年第2期63-65,共3页Shandong Chemical Industry

基　　金：广西高校中青年教师科研基础能力提升项目(2019KY0853,2020KY23016)。

摘　　要：以2-吡啶甲醛和3-吡咯-氨基硫脲合成了缩氨基硫脲配体,再与氯化铋反应合成了铋配合物。通过单晶衍射获得其单晶结构,每个铋配合物分子里面包含四个配体和四个铋中心。通过MTT实验测试了铋配合物在体外对多种癌细胞株(人膀胱癌细胞株T24、人肺癌细胞株A549、人胃癌细胞株MGC-803和人乳腺癌细胞株MDA-MB-231)的抗肿瘤活性。结果显示铋配合物展现出良好的抗肿瘤活性,且活性优于顺铂。Thiosemicarbazone ligand was synthesized with 2-pyridinecarboxaldehyde and 3-pyrrole-thiosemicarbazide,and then the Bi(Ⅲ)complex was synthesized by reaction with bismuth chloride.The structure was obtained by single crystal diffraction,and each molecule of Bi(Ⅲ)complex contained four ligands and four Bi centers.The anti-tumor activity of the Bi(Ⅲ)complex was tested in vitro against various cancer cell lines(human bladder cancer cell line T24,human lung cancer cell line A549,human gastric cancer cell line MGC-803 and human breast cancer cell line MDA-MB-231)by MTT assay.The results showed that the Bi(Ⅲ)complex exhibited good antitumor activity and the activity was superior to that of cisplatin.

关 键 词：铋配合物 抗肿瘤活性 缩氨基硫脲 

分 类 号：O614.821[理学—无机化学]