Exercise training-induced changes in exerkine concentrations may be relevant to the metabolic control of type 2 diabetes mellitus patients:A systematic review and meta-analysis of randomized controlled trials  

作　　者：Antonio García-Hermoso Robinson Ramírez-Vélez Javier Díez Arantxa González Mikel Izquierdo 

机构地区：[1]Navarrabiomed,Public University of Navarra(UPNA),Health Research Institute of Navarra(IdiSNA),University Hospital of Navarra,Pamplona 310008,Spain [2]CIBER of Frailty and Healthy Aging(CIBERFES),Carlos Ⅲ Institute of Health,Madrid 28029,Spain [3]Institute for Health Research of Navarra(IDISNA),Pamplona 31008,Spain [4]Program of Cardiovascular Diseases,Center for Applied Medical Research,University of Navarra,Pamplona 31008,Spain [5]Centre for Biomedical Research in Cardiovascular Disease Network,Carlos Ⅲ Institute of Health,Madrid 28029,Spain [6]Departments of Nephrology and Cardiology,University of Navarra Clinic,Pamplona 31008,Spain

出　　处：《Journal of Sport and Health Science》2023年第2期147-157,共11页运动与健康科学（英文）

摘　　要：Background:This study investigates the effects of exercise training on exerkines in patients with type 2 diabetes mellitus to determine the optimal exercise prescription.Methods:A systematic search for relevant studies was performed in 3 databases.Randomized controlled trials investigating the effects of exercise training on at least one of the following exerkines were included:adiponectin,apelin,brain-derived neurotrophic factor,fetuin-A,fibroblast growth factor-21,follistatin,ghrelin,interleukin(IL)-6,IL-8,IL-10,IL-15,IL-18,leptin,myostatin,omentin,resistin,retinol-binding protein 4,tumor necrosis factor-α,and visfatin.Results:Forty randomized controlled trials were selected for data extraction(n=2160).Exercise training induces changes in adiponectin,fetuin-A,fibroblast growth factor-21,IL-6,IL-10,leptin,resistin,and tumor necrosis factor-a levels but has no significant effects on apelin,IL-18,and ghrelin compared to controls.Physical exercise training favored large and positive changes in pooled exerkines(i.e.,an overall effect size calculated from several exerkine s)(Hedge’s g=1.02,95%confidence interval(95%CI):0.76-1.28),which in turn were related to changes in glycated hemoglobin(mean difference(MD)=-0.81%,95%CI:-0.95%to-0.67%),fasting glucose(MD=-23.43 mg/dL,95%CI:-30.07 mg/dL to-16.80 mg/dL),waist circumference(MD=-3.04 cm,95%CI:-4.02 cm to-2.07 cm),and body mass(MD=-1.93 kg,95%CI:-2.00 kg to-1.86 kg).Slightly stronger effects were observed with aerobic,resistance,or high-intensity interval protocols at moderate-to vigorous-intensity and with programs longer than 24 weeks that comprise at least 3 sessions per week and more than 60 min per session.Conclusion:Exercise training represents an anti-inflammatory therapy and metabolism-improving strategy with minimal side effects for patients with type 2 diabetes mellitus.

关 键 词：ADIPOKINES Exercise training Hepatokines MYOKINES 

分 类 号：R587.1[医药卫生—内分泌] G808.1[医药卫生—内科学]