The etiology,risk factors,and management of sarcopenia and metabolic dysfunction-associated steatotic liver disease(MASLD)are comparable,which prompted the investigators to search for a particular diagnostic or progno...
BACKGROUND Skeletal muscle alterations(SMAs)are being increasingly recognized in patients with metabolic dysfunctionassociated steatotic liver disease(MASLD)and appear to be associated with deleterious outcomes in the...
Cancer is a major cause of morbidity and mortality worldwide,and the incidence is increasing,highlighting the need for effective strategies to treat this disease.Exercise has emerged as fundamental therapeutic medicin...
supported by grants from the National Key Research and Development Program of China(2018YFA0800403 and 2021YFC2701903);the Training Program of the Major Research Plan of the National Natural Science Foundation of China(91857110);the National Natural Science Foundation of China(81670740,32000817,82100904,and 82300910);the National Natural Science Fund for Excellent Young Scholars of China(81722012);the Zhejiang Provincial Natural Science Foundation of China(LZ21H070001,LHDMD22H02001,and LHDMD24H030001);the Innovative Institute of Basic Medical Sciences of Zhejiang University,and the Fundamental Research Funds for the Central Universities.
Skeletal muscle plays a vital role in the regulation of systemic metabolism,partly through its secretion of endocrine factors which are collectively known as myokines.Altered myokine levels are associated with metabol...
Inflammatory bowel disease(IBD),including Crohn’s disease and ulcerative colitis,showed a wide spectrum of intestinal and extra-intestinal manifestations,which rendered the patients physically inactive and impaired t...
Background:This study investigates the effects of exercise training on exerkines in patients with type 2 diabetes mellitus to determine the optimal exercise prescription.Methods:A systematic search for relevant studie...
supported by Lee Kong Chian MedTech Initiative,Singapore(N-176-000-045-001);the Institute for Health Innovation&Technology,iHealthtech,at the National University of Singapore;funded by Lee Kong Chian MedTech Initiative,Singapore.
An organism’s survival depends on its ability to adapt to stress.Mitochondria are the cellular integrators of environmental stressors that ultimately translate their responses at the organismal level,and are thus cen...
In a recent study published in Cancer Cell,Kurz et al.reported how exercise induces inhibitory effects on tumor growth by immuno-logical processes.1The investigation of these mechanisms is particularly signifcant beca...
Diabetes mellitus, a type of chronic metabolic disease, is occurring more frequently and causes severe threats to human health. In vivo, exercise can stimulate skeletal muscle cells to secrete and release myokines int...
This work was supported by National Institutes of Health Grants R01 CA-121249(National Cancer Institute)and R21 CA-231131 to JAC.
Low-grade inflammation is emerging as a common feature of contemporary metabolic,psychiatric,and neurodegenerative diseases.Both physical inactivity and abdominal adiposity are associated with persistent systemic low-...