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Assessment of skeletal muscle alterations and circulating myokines in metabolic dysfunction-associated steatotic liver disease:A crosssectional study: 《World Journal of Gastroenterology》2025年第7期63-73,共11页Yolanda Real Martinez Carlos Ernesto Fernandez-Garcia Esther Fuertes-Yebra Mario Calvo Soto Angela Berlana Vicente Barrios Maria Caldas Leticia Gonzalez Moreno Luisa Garcia-Buey Begoña Molina Baena Miguel Sampedro-Nuñez Maria J Beceiro C García-Monzón Águeda González-Rodríguez; BACKGROUND Skeletal muscle alterations(SMAs)are being increasingly recognized in patients with metabolic dysfunctionassociated steatotic liver disease(MASLD)and appear to be associated with deleterious outcomes in the...; 关键词：Skeletal muscle alterations MYOKINES Metabolic dysfunction-associated steatotic liver disease Liver fibrosis HEPATOSTEATOSIS

The deubiquitinating enzyme 13 retards non-alcoholic steatohepatitis via blocking inactive rhomboid protein 2-dependent pathway被引量：2: 《Acta Pharmaceutica Sinica B》2023年第3期1071-1092,共22页Minxuan Xu Jun Tan Liancai Zhu Chenxu Ge Wei Dong Xianling Dai Qin Kuang Shaoyu Zhong Lili Lai Chao Yi Qiang Li Deshuai Lou Linfeng Hu Xi Liu Gang Kuang Jing Luo Jing Feng Bochu Wang; supported by National Natural Science Foundation of China(NSFC Grant Nos.81703527 and 82200652);Chongqing Research Program of Basic Research and Frontier Technology(Grant Nos.cstc2017jcyjAX0356,cstc2018jcyjA3686,cstc2018jcyjAX0784,cstc2018jcyjA1472,cstc2018jcyjAX0811,cstc2018jcyjA3533,and KJZD-M201801601,China);School-level Research Program of Chongqing University of Education(Grant Nos.KY201710B and 17GZKP01,China);Advanced Programs of Post-doctor of Chongqing(Grant No.2017LY39,China);Science and Technology Research Program of Chongqing Education Commission of China(Grant Nos.KJQN201901608,KJQN201901615,KJ1601402,and KJZDK202001603);Children's Research Institute of National Center for Schooling Development Programme and Chongqing University of Education(Grant No.CSDP19FSO1108,China);Chongqing Professional Talents Plan for Innovation and Entrepreneurship Demonstration Team(CQCY201903258,China).; Nowadays potential preclinical drugs for the treatment of nonalcoholic steatohepatitis(NASH)have failed to achieve expected therapeutic efficacy because the pathogenic mechanisms are underestimated.Inactive rhomboid p...; 关键词：Usp13 Irhom2 NASH HEPATOSTEATOSIS Ubc13 NAFLD UBIQUITINATION Liver inflammation

Relationship between non-alcoholic fatty liver disease and coronary heart disease被引量：2: 《World Journal of Clinical Cases》2020年第20期4688-4699,共12页Ugur Arslan Mustafa Yenerçağ; Non-alcoholic fatty liver disease(NAFLD)is the leading cause of chronic liver disease and considered a liver manifestation of metabolic syndrome.It is in close relationship with insulin resistance,obesity,diabetes mel...; 关键词：Fatty liver HEPATOSTEATOSIS Coronary heart disease ATHEROSCLEROSIS CARDIOVASCULAR ARTERY

Ganoderma lucidum polysaccharide peptide alleviates hepatoteatosis via modulating bile acid metabolism dependent on FXR-SHP/FGF被引量：1: 《中国药理学与毒理学杂志》2019年第9期703-704,共2页ZHONG Dan-dan YANG Bao-xue; National Natural Science Foundation of China(81330074;81620108029;81261160507);Beijing Natural Science Foundation(7172113); OBJECTIVE Ganoderma lucidum polysaccharide peptide(GLPP)is a group of extract from Ganoderma lucidum with a molecular mass of approximately 5×10^5,which ratio of polysaccharide to peptide is approximately 95%/5%.The ...; 关键词：Ganoderma lucidum polysaccharide peptide NAFLD insulin resistance HEPATOSTEATOSIS metabolo⁃mics bile acid synthesis nuclear receptors fatty acid synthesis

Lingguizhugan decoction attenuates diet-induced obesity and hepatosteatosis via gut microbiota被引量：18: 《World Journal of Gastroenterology》2019年第27期3590-3606,共17页Meng-Ting Liu Ying-Juan Huang Ting-Ying Zhang Lun-Bo Tan Xi-Feng Lu Jian Qin; the National Natural Science Foundation of China,No.81874498; BACKGROUND Obesity is a major risk factor for a variety of diseases such as diabetes,nonalcoholic fatty liver disease, and cardiovascular diseases. Restricting energy intake, or caloric restriction(CR), can reduce bod...; 关键词：OBESITY Diabetes LIPID metabolism HEPATOSTEATOSIS GUT MICROBIOTA

Repurposing matrine for the treatment of hepatosteatosis and associated disorders in glucose homeostasis in mice被引量：2: 《Acta Pharmacologica Sinica》2018年第11期1753-1759,共7页Ali Mahzari Xiao-Yi Zeng Xiu Zhou Songpei Li Jun Xu Wen Tan Ross Vlahos Stephen Robinson Ji-Ming YE; The present study investigated the efficacy of the hepatoprotective drug matrine （Mtr） for its new application for hepatosteatosis and associated disorders in glucose homeostasis. The study was performed in two nutr...; 关键词：MATRINE HEPATOSTEATOSIS glucose intolerance hyperglycemic control

C-peptide as a key risk factor for non-alcoholic fatty liver disease in the United States population被引量：8: 《World Journal of Gastroenterology》2018年第32期3663-3670,共8页Amporn Atsawarungruangkit Jirat Chenbhanich George Dickstein; AIM To determine whether fasting C-peptide is an independent predictor for non-alcoholic fatty liver disease(NAFLD) in United States population.METHODS Using the National Health and Nutrition Examination Survey(NHANES...; 关键词：INSULIN resistance FATTY liver HEPATOSTEATOSIS METABOLIC syndrome C-PEPTIDE

Gentiopicroside ameliorates LKB1/AMPK-dependent alcoholic hepatosteatosis via P2x7R-NLRP3 inflammasome被引量：3: 《中国药理学与毒理学杂志》2018年第4期265-266,共2页Xia LI Yu ZHANG Kai-li XIA Min JIANG Ben-wen CUI Yan-ling WU Ji-xing NAN Li-hua LIAN; supported by National Natural Science Foundation of China(81560597;81260664;81360658;81660689); OBJECTIVE Regulating P2x7R-NLRP3 inflammasome activation might be a potential therapeutic strategy to treat alcoholic hepatosteatosis.We investigated whether this process would be modulated by gentiopicroside(GPS),whi...; 关键词：炎症酒精肝治疗方法临床分析

Delayed ethanol elimination and enhanced susceptibility to ethanol-induced hepatosteatosis after liver resection: 《World Journal of Gastroenterology》2014年第48期18249-18259,共11页Xu Liu Ayako Hakucho Jinyao Liu Tatsuya Fujimiya; Supported by Japan Society for the Promotion of Science’s Grants-in-Aid for Scientific Research,No.22590635; AIM: To investigate ethanol-induced hepatic steatosis after liver resection and the mechanisms behind it.; 关键词：ETHANOL Hepatic class-1 alcohol dehydrogenase Ethanol elimination Hepatic steatosis Liver function Liver resection

C/EBP beta and C/EBP delta expression is elevated in the early phase of ethanol-induced hepatosteatosis in mice: 《Acta Pharmacologica Sinica》2009年第8期1138-1143,共6页Yu-hsuan CHEN Chih-min YANG Shih-pei CHANG Miao-lin HU; Aim： Alcohol, which is predominantly metabolized in the liver, is a major hepatic toxicant that readily induces hepatic steatosis. The expression of CCAAT enhancer binding protein （C/EBP）, especially the C/EBP delt...; 关键词：C/EBP delta ETHANOL HEPATOSTEATOSIS ADIPOGENESIS

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