Relationship between non-alcoholic fatty liver disease and coronary heart disease  

作　　者：Ugur Arslan Mustafa Yenerçağ 

机构地区：[1]Department of Cardiology,University of Health Sciences Samsun Training and Research Hospital,Samsun 55400,Turkey

出　　处：《World Journal of Clinical Cases》2020年第20期4688-4699,共12页世界临床病例杂志

摘　　要：Non-alcoholic fatty liver disease(NAFLD)is the leading cause of chronic liver disease and considered a liver manifestation of metabolic syndrome.It is in close relationship with insulin resistance,obesity,diabetes mellitus,all of which increase risk of cardiovascular disease(CVD).Besides,many studies point out that NAFLD independently contributes to the development of atherosclerosis and CHD.On the other hand,CVDs are the leading cause of death in NAFLD patients.Many pathophysiological changes and molecular mechanisms play an important role in NAFLD for CVD formation.Atherosclerosis is common in NAFLD,which also mainly contributes to the CVD formation and CHD.Many studies linking atherosclerotic CHD and NAFLD are present in the literature.Subclinical CHD,mainly detected by coronary computed tomography views,have been detected more common in NAFLD patients.Presence of NAFLD has been found to be more common in patients with severe CHD and in stable CHD,NAFLD has been found to be associated with more diffuse disease.In acute coronary syndromes,especially in acute myocardial infarction,patients with NAFLD have been found to have poor prognosis when compared with NAFLD free patients.In this review,our aim is to evaluate the relationship between NAFLD and CHD in detail and go over the pathophysiological mechanisms underlying this relationship.

关 键 词：Fatty liver HEPATOSTEATOSIS Coronary heart disease ATHEROSCLEROSIS CARDIOVASCULAR ARTERY 

分 类 号：R575.5[医药卫生—消化系统] R541.4[医药卫生—内科学]