Suppressive effects of exercise-conditioned serum on cancer cells:A narrative review of the influence of exercise mode,volume,and intensity  

作　　者：Francesco Bettariga Dennis R.Taaffe Daniel A.Galvao Chris Bishop Jin-Soo Kim Robert U.Newton 

机构地区：[1]Exercise Medicine Research Institute,Edith Cowan University,Joondalup,WA 6027,Australia [2]School of Medical and Health Sciences,Edith Cowan University,Joondalup,WA 6027,Australia [3]London Sport Institute,School of Science and Technology,Middlesex University,London,NW44BT,UK [4]School of Human Movement and Nutrition Sciences,University of Queensland,St.Lucia,QLD 4072,Australia

出　　处：《Journal of Sport and Health Science》2024年第4期484-498,F0003,共16页运动与健康科学（英文）

摘　　要：Cancer is a major cause of morbidity and mortality worldwide,and the incidence is increasing,highlighting the need for effective strategies to treat this disease.Exercise has emerged as fundamental therapeutic medicine in the management of cancer,associated with a lower risk of recur-rence and increased survival.Several avenues of research demonstrate reduction in growth,proliferation,and increased apoptosis of cancer cells,including breast,prostate,colorectal,and lung cancer,when cultured by serum collected after exercise in vitro(i.e.,the cultivation of cancer cell lines in an experimental setting,which simplifies the biological system and provides mechanistic insight into cell responses).The underlying mechanisms of exercise-induced cancer suppressive effects may be attributed to the alteration in circulating factors,such as skeletal muscle-induced cytokines(i.e.,myokines)and hormones.However,exercise-induced tumor suppressive effects and detailed information about training interventions are not well investigated,constraining more precise application of exercise medicine within clinical oncology.To date,it remains unclear what role different training modes(i.e.,resistance and aerobic training)as well as volume and intensity have on exercise-condi-tioned serum and its effects on cancer cells.Nevertheless,the available evidence is that a single bout of aerobic training at moderate to vigorous intensity has cancer suppressive effects,while for chronic training interventions,exercise volume appears to be an influential candidate driving cancer inhibitory effects regardless of training mode.Insights for future research investigating training modes,volume and intensity are provided to further our understanding of the effects of exercise-conditioned serum on cancer cells.

关 键 词：Cancer cells High intensity interval training Moderate intensity continuous training Resistance training MYOKINES 

分 类 号：G804.2[文化科学—运动人体科学] R730[文化科学—体育学]