Interaction between inflammatory bowel disease,physical activity,and myokines:Assessment of serum irisin levels  

作　　者：Marwan SM Al-Nimer 

机构地区：[1]Department of Therapeutics and Clinical Pharmacology,College of Medicine,University of Diyala,Baqubah 32001,Iraq

出　　处：《World Journal of Gastroenterology》2024年第22期2923-2926,共4页世界胃肠病学杂志（英文版）

摘　　要：Inflammatory bowel disease(IBD),including Crohn’s disease and ulcerative colitis,showed a wide spectrum of intestinal and extra-intestinal manifestations,which rendered the patients physically inactive and impaired their quality of life.It has been found that physical activity is a non-pharmacological intervention that improves the quality of life for those patients.Irisin is one member of the myokines secreted by muscle contraction during exercise and could be used as an antiinflammatory biomarker in assessing the physical activity of IBD patients.In addition,experimental studies showed that exogenous irisin significantly decreased the inflammatory markers and the histological changes of the intestinal mucosa observed in experimental colitis.Furthermore,irisin produces changes in the diversity of the microbiota.Therefore,endogenous or exogenous irisin,via its anti-inflammatory effects,will improve the health of IBD patients and will limit the barriers to physical activity in patients with IBD.

关 键 词：Irisin Inflammatory bowel disease Physical activity MYOKINES Prognostic marker 

分 类 号：R574[医药卫生—消化系统]