Effects of Kangfuxin Solution (康复新液) Combined with Low-level Laser on Cytokines and Immune Function in Patients with Radiation-induced Oral Mucositis  

作　　者：董克臣 张萌 李松 DONG Ke-chen;ZHANG Meng;LI Song(Department of Oncology of Head and Neck,Huangshi Central Hospital,Affiliated Hospital of Hubei Polytechnic University,E Dong Healthcare Group,Huangshi 435200,China;Hubei Key Laboratory of Kidney Disease Pathogenesis and Intervention,Huangshi 435200,China)

机构地区：[1]Department of Oncology of Head and Neck,Huangshi Central Hospital,Affiliated Hospital of Hubei Polytechnic University,E Dong Healthcare Group,Huangshi 435200,China [2]Hubei Key Laboratory of Kidney Disease Pathogenesis and Intervention,Huangshi 435200,China

出　　处：《World Journal of Integrated Traditional and Western Medicine》2023年第1期23-28,共6页世界中西医结合杂志（英文）

摘　　要：Objective:To investigate the effect of Kangfuxin Solution(康复新液)combined with low-level laser therapy(LLLT)on cytokines and immune function in patients with radiation-induced oral mucositis.Methods:There were 84 nasopharyngeal carcinoma patients with oral mucositis after intensity-modulated radiation therapy(IMRT)were randomly divided into the control group(CG)and the observation group(OG),with 42 cases in each group.The CG was given LLLT,and the OG was treated with Kangfuxin Solution in addition to LLLT for 10 consecutive days.The healing time of oral mucosa,mucositis grading,oral pain scores,cytokines(interleukin-6,interleukin-1βand tumor necrosis factor-α)and T lymphocyte subsets were compared between the 2 groups before and after treatment.Results:The healing time of oral mucosa in the OG was(6.8±1.4)d,which was significantly shorter than(8.6±1.9)d in the CG(t=4.943,P<0.01).After treatment,the grading of oral mucositis in the OG was better than that in the CG,with a statistically significant difference(Z=2.942,P<0.05).The oral pain scores of the OG was lower than that in the CG at different time points after treatment,and the difference was statistically significant(t=8.207,11.017,P<0.01).After treatment,the levels of IL-6,IL-1βand TNF-αin peripheral blood of the OG were significantly lower than those in the CG(t=5.217,2.775,4.053,P<0.01).There were statistically significant differences in CD4+,CD8+and CD4+/CD8+between the OG and the CG after treatment(t=5.692,6.093,3.658,P<0.01).Conclusion:Kangfuxin Solution combined with LLLT can significantly shorten the healing time of oral mucosal,reduce the grading of oral mucositis,relieve oral pain,reduce inflammatory response and improve the immune function of patients.

关 键 词：Radiation-induced oral mucositis Nasopharyngeal carcinoma Kangfuxin Solution Low-level laser therapy CYTOKINES Immune function 

分 类 号：R739.63[医药卫生—肿瘤]