化学发光免疫测定技术在甲状腺肿瘤检验中的价值  

Value of Chemiluminescence Immunoassay in Thyroid Tumor Detection

作　　者：王继芳 WANG Jifang(Jingshan Renhe Hospital Of Hubei,Jingshan,Hubei 431800)

机构地区：[1]湖北京山仁和医院,湖北京山431800

出　　处：《智慧健康》2023年第2期9-13,共5页Smart Healthcare

摘　　要：目的 探讨化学发光免疫测定技术在甲状腺肿瘤检验中的价值。方法 从2019年4月-2021年4月选择136例疑似甲状腺肿瘤患者,所选患者均实施血液免疫检验,空腹状态下采集静脉血10mL,将血液样本等分成2份,一份通过放射免疫法进行检验,另一份通过化学发光免疫测定技术检验,并以术后病理检查所得结果为金标准,对这两种检验方式的球蛋白水平、甲状腺球蛋白水平、游离三碘甲状腺原氨酸水平、促甲状腺素水平、游离甲状腺素水平、降钙素水平、抗甲状腺球蛋白抗体水平、抗甲状腺过氧化物酶抗体水平进行比较分析,并对两种检验方式的临床价值进行对比分析。结果 化学发光免疫测定技术球蛋白水平检验结果、甲状腺球蛋白水平检验结果、游离三碘甲状腺原氨酸水平检验结果、促甲状腺素水平检验结果、游离甲状腺素水平检验结果、降钙素水平检验结果、抗甲状腺球蛋白抗体水平检验结果、抗甲状腺过氧化物酶抗体水平检验结果均高于放射免疫法(P<0.05)。化学发光免疫测定技术检验符合率(94.12%)高于放射免疫法(76.47%)(P<0.05);化学发光免疫测定技术检验特异度(96.88%)高于放射免疫法(81.25%)(P<0.05);化学发光免疫测定技术检验灵敏度(91.67%)高于放射免疫法(72.22%)(P<0.05)。结论 在甲状腺肿瘤检验中,化学发光免疫测定技术的应用可以提高检验临床价值,使检验结果更加准确、可靠,为疾病诊断及治疗提供支持。Objective To explore value of chemiluminescence immunoassay in detection of thyroid tumors.Methods The paper chose 136 patients with suspected thyroid tumor with blood immune test from April 2019 to April 2021,collected 10mL of venous blood under fasting condition,and divided them into two equal parts.One was tested by radioimmunoassay,the other by chemiluminescence immunoassay.With gold standard of postoperative pathological examination results of thyroglobulin,free triiodothyronine,thyrotropin,free thyroxine,calcitonin,anti-thyroglobulin antibody and anti-thyroid peroxidase antibody was compared and analyzed,clinical value between two test methods was compared and analyzed.Results Globulin level of chemiluminescence immunoassay was higher than radioimmunoassay(P<0.05);level of thyroglobulin by chemiluminescence immunoassay was higher than radioimmunoassay(P<0.05);level of free triiodothyronine by chemiluminescence immunoassay was higher than radioimmunoassay(P<0.05);result of thyrotropin level test by chemiluminescence immunoassay was higher than radioimmunoassay(P<0.05);level of free thyroxine in chemiluminescence immunoassay was higher than radioimmunoassay(P<0.05);calcitonin level test result by chemiluminescence immunoassay was higher than radioimmunoassay(P<0.05);results of anti-thyroglobulin antibody level by chemiluminescence immunoassay were higher than radioimmunoassay(P<0.05);results of anti-thyroid peroxidase antibody level by chemiluminescence immunoassay were higher than radioimmunoassay(P<0.05).Coincidence rate of chemiluminescence immunoassay(94.12%)was higher than radioimmunoassay(76.47%),P<0.05;specificity of chemiluminescence immunoassay(96.88%)was higher than radioimmunoassay(81.25%),P<0.05;sensitivity of chemiluminescence immunoassay(91.67%)was higher than radioimmunoassay(72.22%),P<0.05.Conclusion Chemiluminescence immunoassay can improve clinical value of thyroid tumor test,make the test results more accurate and reliable,and provide support for disease diagnosis and treatment in detection

关 键 词：免疫检验 化学发光免疫测定技术 放射免疫法 诊断价值 

分 类 号：R736.1[医药卫生—肿瘤]