化痰通腑法联合氯吡格雷治疗脑梗死近期疗效及对炎症因子水平和神经功能缺损的影响  

Short-term therapeutic efficacy of Huatan Tongfu Therapy combined with clopidogrel on cerebral infarction and its impacts on inflammatory factor levels and neurological deficits

作　　者：刘少检 郑国雄 LIU Shaojian;ZHENG Guoxiong(DepartmentⅠof Internal Medicine,Hospital of Traditional Chinese Medicine in Raoping County,Guangdong,Raoping 515700,China)

机构地区：[1]广东省饶平县中医医院内一科,广东饶平515700

出　　处：《中国医药科学》2023年第5期121-124,137,共5页China Medicine And Pharmacy

基　　金：广东省潮州市卫生健康局科研项目(潮卫科研2021064)。

摘　　要：目的 分析脑梗死患者采用化痰通腑法与氯吡格雷联合治疗的近期疗效,探讨其对神经功能缺损和炎症因子水平的影响。方法 选取2021年4月至2022年4月饶平县中医医院内一科收治的80例脑梗死患者作为研究对象,按照随机数表法分为两组,所有患者均行基础性治疗,在此基础上,给予对照组(n=40)氯吡格雷治疗,给予观察组(n=40)氯吡格雷联合化痰通腑法治疗。比较两组的近期疗效、神经功能缺损评分、血清炎症因子水平变化等。结果 观察组治疗总有效率为95.00%,高于对照组的80.00%,差异有统计学意义(P <0.05)。经过10 d治疗,观察组血清C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)水平低于对照组,差异有统计学意义(P <0.05)。治疗后1、3个月,观察组患者的美国国立卫生研究院卒中量表(NIHSS)评分、脑卒中改良Rankin量表(mRS)评分均低于对照组,差异有统计学意义(P <0.05)。结论 化痰通腑法联合氯吡格雷治疗,可有效减轻脑梗死患者的炎症反应,改善神经功能,提高近期疗效,有利于改善预后,具有重要的研究价值。Objective To analyze the short-term therapeutic efficacy of Huatan Tongfu Therapy combined with clopidogrel in patients with cerebral infarction,and to investigate its impacts on inflammatory factor levels and neurological deficits.Methods A total of 80 patients with cerebral infarction admitted to and treated in the DepartmentⅠof Internal Medicine in the Hospital of Traditional Chinese Medicine in Raoping County from April 2021 to April 2022 were selected as the research objects,and they were divided into the control group(n=40)and the observation group(n=40)according to the random number table method.All patients were given basic treatment.On this basis,the control group was treated with clopidogrel,while the observation group was treated with clopidogrel combined with Huatan Tongfu Therapy.The short-term therapeutic efficacy,neurological deficit scores and changes of serum inflammatory factor levels were compared between the two groups.Results The overall response rate of treatment was 95.00%in the observation group,higher than 80.00%in the control group,with statistically significant difference(P<0.05).After 10 days of treatment,the levels of serum C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)in the observation group were lower than those in the control group,with statistically significant differences(P<0.05).After 1 and 3 months of treatment,the scores of National institute of health stroke scale(NIHSS)and modified rankin scale(mRS)of the patients in the observation group were all lower than those of the patients in the control group,with statistically significant differences(P<0.05).Conclusion The Huatan Tongfu Therapy combined with clopidogrel can effectively alleviate the inflammatory reaction of patients with cerebral infarction,improve their neurological function,increase their short-term therapeutic efficacy,and help to ameliorate the prognosis.Therefore,it has important research significance.

关 键 词：脑梗死 氯吡格雷 化痰通腑法 神经功能缺损 

分 类 号：R743.3[医药卫生—神经病学与精神病学]